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首页> 外文期刊>Materials science & engineering >Synthesis and characterization of nanocrystalline forsterite coated poly(L-lactide-co-β-malic acid) scaffolds for bone tissue engineering applications
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Synthesis and characterization of nanocrystalline forsterite coated poly(L-lactide-co-β-malic acid) scaffolds for bone tissue engineering applications

机译：纳米晶镁橄榄石包覆的聚（L-丙交酯-β-苹果酸）支架的合成与表征

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摘要

In this research, after synthesizing poly(L-lactide-co-β-malic acid) (PLMA) copolymer, hybrid particles of ice and nanocrystalline forsterite (NF) as coating carriers were used to prepare NF-coated PLMA scaffolds. The porous NF-coated scaffolds were directly fabricated by a combined technique using porogen leaching and freeze-drying methods. The obtained results indicate that the scaffolds were structurally porous with NF particles on their surfaces. When compared to the uncoated scaffolds, the NF coating improved both mechanical properties as well as enhanced bioactivity of the scaffolds. In addition, in vitro biological response of the rat bone marrow stromal cells indicated that NF significantly increased the biocompatibility of NF-coated scaffolds compared with PLMA.
机译：在这项研究中，合成聚（L-丙交酯-共-β-苹果酸）（PLMA）共聚物后，冰和纳米晶镁橄榄石（NF）的混合颗粒作为涂层载体被用来制备NF涂层的PLMA支架。多孔的NF涂层支架是使用造孔剂浸出和冷冻干燥的组合技术直接制造的。所得结果表明支架在结构上是多孔的，表面上有NF颗粒。当与未涂覆的支架相比较时，NF涂层改善了支架的机械性能以及增强的生物活性。此外，大鼠骨髓基质细胞的体外生物学反应表明，与PLMA相比，NF显着提高了NF涂层支架的生物相容性。

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  • 来源
    《Materials science & engineering》 |2015年第5期|117-123|共7页
  • 作者

    M. Mozafari; M. Gholipourmalekabadi; N.P.S. Chauhan; N. Jalali; S. Asgari; J.C. Caicedoa; A. Hamlekhan; A.M. Urbanska;

  • 作者单位

    Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 14155-4777, Tehran, Iran;

    Biotechnology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

    Department of Chemistry, Bhupal Nobles Post Graduate College, Udaipur 313001, Rajasthan, India;

    Biomaterial Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, P.O. Box: 15875-4413, Tehran, Iran;

    Computational Physiology and Biology Laboratory, Department of Computer Engineering and Computer Science, California State University, Long Beach, CA 90840, USA;

    Tribology, Powder Metallurgy and Processing of Solid Recycled Research Group, Universidad del Valle, Cali, Colombia;

    Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, MI 49931, USA;

    Division of Digestive and Liver Diseases, Department of Medicine, Irving Cancer Research Center, Columbia University New York, NY 10032, USA;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Scaffold; Coating; Tissue engineering; Biocompatibility;

    机译：脚手架;涂层;组织工程;生物相容性;

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