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首页> 外文期刊>Materials science & engineering >Graphene oxide based magnetic nanocomposites for efficient treatment of breast cancer
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Graphene oxide based magnetic nanocomposites for efficient treatment of breast cancer

机译：氧化石墨烯基磁性纳米复合材料可有效治疗乳腺癌

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摘要

The present work reports a simple one step synthesis of nanoscale graphene oxide magnetic composites (GO-IO) using ferrofluid (GO-IOF). The obtained GO-IO were compared with GO-IO obtained from in situ (GO-IOI) methods. Anastrozole (ANS) was loaded on the GO-IOI and GO-IOF via simple stirring method to form GO-IOA and GO-IOFA respectively. These GO-IO prepared by two techniques were characterized using spectroscopic techniques and vibrating sample magnetometer (VSM) analysis. Particle size and potential were measured using Malvern Zetasizer. Scanning electron microscopy (SEM) was used for studying the surface morphology of GO-IO, and in addition to this elemental analysis was also performed for confirming the presence of iron. The cell viability assay was carried out using the MCF-7 cell line. It revealed that GO-IOFA had reasonably high cytotoxicity (49.7%) compared to GO (13.1%), ANS (16.6), GO-IOI (13%), GO-IOF (13.6) and GO-IOIA (18.34%). Both, GO-IOIA and GO-IOFA showed improved cytotoxicity when compared with pure ANS. GO-IOF were found to exhibit superior magnetic activity due to higher iron content along with smaller particle size and higher loading efficiency compared to GO-IOI. The overall effect suggests that GO-IO can be utilized as efficient carriers for the loading of chemotherapeutic agents.
机译：本工作报告了使用铁磁流体（GO-IOF）的纳米级氧化石墨烯磁性复合物（GO-IO）的简单一步合成。将获得的GO-IO与从原位（GO-IOI）方法获得的GO-IO进行比较。通过简单的搅拌方法将阿那曲唑（ANS）加载到GO-IOI和GO-IOF上，分别形成GO-IOA和GO-IOFA。使用光谱技术和振动样品磁力计（VSM）分析对通过两种技术制备的这些GO-IO进行了表征。使用Malvern Zetasizer测量粒度和电势。扫描电子显微镜（SEM）用于研究GO-10的表面形态，此外，还进行了元素分析以确认铁的存在。使用MCF-7细胞系进行细胞活力测定。结果表明，与GO（13.1％），ANS（16.6），GO-IOI（13％），GO-IOF（13.6）和GO-IOIA（18.34％）相比，GO-IOFA具有相当高的细胞毒性（49.7％）。与纯ANS相比，GO-IOIA和GO-IOFA均显示出改善的细胞毒性。与GO-IOI相比，由于GO-IOF具有更高的铁含量，更小的粒径和更高的装载效率，因此发现其具有出众的磁性。总体效果表明GO-10可以用作装载化学治疗剂的有效载体。

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  • 来源
    《Materials science & engineering》 |2014年第4期|278-285|共8页
  • 作者

    Nilesh S. Chaudhari; Abhijeet P. Pandey; Pravin O. Patil; Avinash R. Tekade; Sanjay B. Bari; Prashant K. Deshmukh;

  • 作者单位

    Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist., Dhule 425 405, Maharashtra, India;

    Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist., Dhule 425 405, Maharashtra, India;

    Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist., Dhule 425 405, Maharashtra, India;

    Department of Pharmaceutics, Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune 411 033, Maharashtra, India;

    Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist., Dhule 425 405, Maharashtra, India;

    Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist., Dhule 425 405, Maharashtra, India;

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  • 正文语种 eng
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  • 关键词

    Ferrofluid; Breast cancer; Anastrozole; MCF-7;

    机译：铁磁流体乳腺癌;阿那曲唑MCF-7;

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