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首页> 外文期刊>Materials science & engineering >Understanding anisotropy and architecture in ice-templated biopolymer scaffolds
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Understanding anisotropy and architecture in ice-templated biopolymer scaffolds

机译：了解以冰为模板的生物聚合物支架的各向异性和结构

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摘要

Biopolymer scaffolds have great therapeutic potential within tissue engineering due to their large interconnected porosity and biocompatibility. Using an ice-templated technique, where collagen is concentrated into a porous network by ice nucleation and growth, scaffolds with anisotropic pore architecture can be created, mimicking natural tissues like cardiac muscle and bone. This paper describes a systematic set of experiments undertaken to understand the effect of local temperatures on architecture in ice-templated biopolymer scaffolds. The scaffolds within this study were at least 10 mm in all dimensions, making them applicable to critical sized defects for biomedical applications. It was found that monitoring the local freezing behavior within the slurry was critical to predicting scaffold structure. Aligned porosity was produced only in parts of the slurry volume which were above the equilibrium freezing temperature (0℃) at the time when nucleation first occurs in the sample as a whole. Thus, to create anisotropic scaffolds, local slurry cooling rates must be sufficiently different to ensure that the equilibrium freezing temperature is not reached throughout the slurry at nucleation. This principal was valid over a range of collagen slurries, demonstrating that by monitoring the temperature within slurry during freezing, scaffold anisotropy with ice-templated scaffolds can be predicted.
机译：生物聚合物支架因其相互关联的大孔隙率和生物相容性而在组织工程领域具有巨大的治疗潜力。使用以冰为模板的技术，通过冰的成核和生长将胶原蛋白浓缩到一个多孔网络中，可以创建具有各向异性孔结构的支架，模仿心肌和骨骼等自然组织。本文介绍了一组系统的实验，以了解局部温度对以冰为模板的生物聚合物支架中结构的影响。这项研究中的支架在所有尺寸上至少为10 mm，使其适用于生物医学应用中的关键尺寸缺陷。已发现监测浆料中的局部冻结行为对于预测支架结构至关重要。在整个样品中，只有在首次成核时，在高于平衡冷冻温度（0℃）的部分浆料体积中才产生对齐的孔隙率。因此，为了产生各向异性的支架，局部浆液的冷却速率必须足够不同以确保成核时整个浆液均未达到平衡冷冻温度。该原理在一系列胶原蛋白浆料中均有效，表明通过监测冷冻过程中浆料中的温度，可以预测以冰为模板的支架的支架各向异性。

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  • 来源
    《Materials science & engineering》 |2014年第4期|141-147|共7页
  • 作者

    K.M. Pawelec; A. Husmann; S.M. Best; R.E. Cameron;

  • 作者单位

    Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, UK;

    Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, UK;

    Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, UK;

    Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, UK;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Scaffold; Collagen; Ice-template; Anisotropy; Tissue engineering;

    机译：脚手架;胶原;冰模板各向异性组织工程;

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