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Determination of the relaxation characteristics of sugar glasses embedded in microfiber substrates

机译：嵌入超细纤维基质中的糖玻璃的弛豫特性的测定

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摘要

Recently there has been considerable interest in developing sugar glasses that enable storage of biologics without refrigeration. Microfiber filter papers are good substrates for drying biologics in the presence of sugar glass-formers, providing for an even distribution of samples and an enhanced surface area for drying, but the opaqueness prevents macroscopic observation of the sample and can introduce complexities that impede physical characterization. Because drying kinetics and processing conditions can impact the relaxation dynamics (e.g., α- and β-relaxation), which can influence the efficacy of the glass as a stabilizer, methods are needed that can enable a determination of relaxation phenomena of sugar glasses in such complex environments. In this study we present a method which provides verification of the absence of crystallinity following drying on glass fiber filter paper and also enables the determination of relaxation characteristics of amorphous sugar compositions embedded within these filter substrates. Using material pockets to contain the sugar glass-embedded microfiber paper, the α-relaxation temperature, T_α, was determined as a function of the water content in trehalose and sucrose samples using Dynamic Mechanical Analysis (DMA). Results were verified by comparison with previous calorimetric and spectroscopic studies. The data also demonstrated the plasticizing effects of water, as T_α was shown to correlate with water content via a Gordon-Taylor-like relationship. Our findings validate a new approach for determining the relaxation characteristics of microfiber embedded sugar glasses, and offer new insights into the relaxation characteristics of glasses prepared by microwave-assisted drying on filter papers.
机译：最近，人们对开发能够在不冷藏的情况下储存生物制剂的糖杯产生了极大的兴趣。超细纤维滤纸是在存在糖玻璃前体的情况下干燥生物制品的良好基材，可提供均匀的样品分布和更大的干燥表面积，但不透明性会阻止对样品进行肉眼观察，并可能导致妨碍物理表征的复杂性。由于干燥动力学和加工条件会影响松弛动力学（例如，α-和β-松弛），从而影响玻璃作为稳定剂的功效，因此需要能够确定糖玻璃松弛现象的方法。复杂的环境。在这项研究中，我们提出了一种方法，该方法可以验证在玻璃纤维滤纸上干燥后不存在结晶度，并且还可以确定嵌入在这些滤膜基质中的无定形糖组合物的弛豫特性。使用材料袋容纳装有糖玻璃的超细纤维纸，使用动态力学分析（DMA）将α松弛温度T_α确定为海藻糖和蔗糖样品中水含量的函数。通过与以前的量热和光谱研究进行比较来验证结果。数据还证明了水的增塑作用，因为T_α通过Gordon-Taylor样关系与水含量相关。我们的发现验证了确定超细纤维嵌入式糖杯的弛豫特性的新方法，并为通过微波辅助滤纸干燥制备的玻璃的弛豫特性提供了新的见解。

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