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首页> 外文期刊>Materials science & engineering >Biocompatible Ni-free Zr-based bulk metallic glasses with high-Zr-content: Compositional optimization for potential biomedical applications
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Biocompatible Ni-free Zr-based bulk metallic glasses with high-Zr-content: Compositional optimization for potential biomedical applications

机译:具有高Zr含量的生物相容性,不含Ni的Zr大块金属玻璃:针对潜在生物医学应用的成分优化

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摘要

The present study designs and prepares Ni-free Zr_(60+x)Ti_(2.5)Al_(10)Fe_(12.5-x)Cu_(10)Ag_5 (at.%, x = 0,2.5,5) bulk metallic glasses (BMGs) by copper mold casting for potential biomedical application. The effects of Zr content on the in vitro biocompatibility of the Zr-based BMGs are evaluated by investigating mechanical properties, bio-corrosion behavior, and cellular responses. It is found that increasing the content of Zr is favorable for the mechanical compatibility with a combination of low Young's modulus, large plasticity, and high notch toughness. Electrochemical measurements demonstrate that the Zr-based BMGs are corrosion resistant in a phosphate buffered saline solution. The bio-corrosion resistance of BMGs is improved with the increase in Zr content which is attributed to the enrichment in Zr and decrease in Al concentration in the surface passive film of alloys. Regular cell responses of mouse MC3T3-E1 cells, including cell adhesion and proliferation, are observed on the Zr-Ti-Al-Fe-Cu-Ag BMGs, which reveals their general biosafety. The high-Zr-based BMGs exhibit a higher cell proliferation activity in comparison with that of pure Zr and Ti-6Al-4V alloy. The effects of Zr content on the in vitro biocompatibility can be used to guide the future design of biocompatible Zr-based BMGs.
机译:本研究设计并制备了无镍Zr_(60 + x)Ti_(2.5)Al_(10)Fe_(12.5-x)Cu_(10)Ag_5(at。%,x = 0,2.5,5)大块金属玻璃(BMG)通过铜模铸造进行潜在的生物医学应用。通过研究机械性能,生物腐蚀行为和细胞反应,可以评估Zr含量对Zr基BMG体外生物相容性的影响。发现增加Zr的含量有利于机械相容性,其具有低杨氏模量,大的可塑性和高的缺口韧性。电化学测量表明,基于Zr的BMG在磷酸盐缓冲盐溶液中具有耐腐蚀性。随着Zr含量的增加,BMG的抗生物腐蚀性能提高,这归因于Zr的富集和合金表面钝化膜中Al浓度的降低。在Zr-Ti-Al-Fe-Cu-Ag BMGs上观察到了小鼠MC3T3-E1细胞的正常细胞应答,包括细胞粘附和增殖,这揭示了它们的一般生物安全性。与纯Zr和Ti-6Al-4V合金相比,高Zr基BMG具有更高的细胞增殖活性。 Zr含量对体外生物相容性的影响可用于指导基于Zr的生物相容性BMG的未来设计。

著录项

  • 来源
    《Materials science & engineering》 |2014年第11期|400-410|共11页
  • 作者单位

    Department of Materials Science and Engineering, Fujian University of Technology, 350118 Fuzhou, China,Department of Materials Science and Engineering, Fuzhou University, 350116 Fuzhou, China;

    Department of Materials Science and Engineering, The University of Tennessee, Knoxville, TN 37996-2100, USA;

    Department of Materials Science and Engineering, Fujian University of Technology, 350118 Fuzhou, China,Department of Materials Science and Engineering, Fuzhou University, 350116 Fuzhou, China;

    Department of Materials Science and Engineering, The University of Tennessee, Knoxville, TN 37996-2100, USA,Department of Mechanical Aerospace and Biomedical Engineering, The University of Tennessee, Knoxville, TN 37996-2200, USA;

    Key Laboratory of Aerospace Materials and Performance (Ministry of Education), School of Materials Science and Engineering, Beihang University, 100191 Beijing, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Bulk metallic glass; Zr-based alloy; Toughness; Bio-corrosion; Cellular response;

    机译:大块金属玻璃;Zr基合金;韧性;生物腐蚀细胞反应;

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