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首页> 外文期刊>Materials science & engineering >Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing
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Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing

机译：载有生长因子的含有壳聚糖微粒的葡聚糖基水凝胶可用于伤口愈合

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摘要

Skin injuries are traumatic events, which are seldom accompanied by complete structural and functional restoration of the original tissue. Different strategies have been developed in order to make the wound healing process faster and less painful. In the present study in vitro and in vivo assays were carried out to evaluate the applicability of a dextran hydrogel loaded with chitosan microparticles containing epidermal and vascular endothelial growth factors, for the improvement of the wound healing process. The carriers' morphology was characterized by scanning electron microscopy. Their cytotoxicity profile and degradation by-products were evaluated through in vitro assays. In vivo experiments were also performed to evaluate their applicability for the treatment of skin burns. The wound healing process was monitored through macroscopic and his-tological analysis. The macroscopic analysis showed that the period for wound healing occurs in animals treated with microparticle loaded hydrogels containing growth factors that were considerably smaller than that of control groups. Moreover, the histological analysis revealed the absence of reactive or granulomatous inflammatory reaction in skin lesions. The results obtained both in vitro and in vivo disclosed that these systems and its degradation by-products are biocompatible, contributed to the re-establishment of skin architecture and can be used in a near future for the controlled delivery of other bioactive agents used in regenerative medicine.
机译：皮肤损伤是创伤性事件，很少伴有原始组织的完整结构和功能恢复。为了使伤口愈合过程更快并且减轻痛苦，已经开发了不同的策略。在本研究中，进行了体外和体内测定，以评估负载有含有表皮和血管内皮生长因子的壳聚糖微粒的右旋糖酐水凝胶的适用性，以改善伤口愈合过程。载体的形态通过扫描电子显微镜表征。通过体外测定评估了它们的细胞毒性谱和降解副产物。还进行了体内实验，以评估其在治疗皮肤烧伤中的适用性。通过宏观和组织学分析监测伤口愈合过程。宏观分析表明，伤口愈合的时间发生在用载有微粒的水凝胶处理的动物中，其中水凝胶的生长因子比对照组小得多。此外，组织学分析表明皮肤病变中没有反应性或肉芽肿性炎症反应。在体外和体内获得的结果表明，这些系统及其降解副产物具有生物相容性，有助于皮肤结构的重建，并且可在不久的将来用于控制再生中使用的其他生物活性剂的输送。药物。

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  • 来源
    《Materials science & engineering》 |2013年第5期|2958-2966|共9页
  • 作者

    M.P. Ribeiro; P.I. Morgado; S.P. Miguel; P. Coutinho; I.J. Correia;

  • 作者单位

    CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhd, Portugal,UDI-IPG, Research Unit for Inland Development, Polytechnic Institute of Guarda, Guarda, Portugal;

    CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhd, Portugal;

    CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhd, Portugal;

    CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhd, Portugal,UDI-IPG, Research Unit for Inland Development, Polytechnic Institute of Guarda, Guarda, Portugal;

    CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhd, Portugal,Av, Infante D, Henrique, 6200-506 Covilha, Portugal;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Wound healing; Drug delivery systems; Biocompatibility; Growth factors; In vivo and in vitro studies;

    机译：伤口愈合;药物输送系统;生物相容性;生长因子;体内和体外研究;

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