Antibiotic-loaded acrylic bone cements: An in vitro study on the release mechanism and its efficacy

Marta Miola; Alessandro Bistolfi; Maria Carmen Valsania; Carlotta Bianco; Giacomo Fucale; Enrica Verne

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Antibiotic-loaded acrylic bone cements: An in vitro study on the release mechanism and its efficacy

机译：加载抗生素的丙烯酸骨水泥的体外释放机理及其功效的研究

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An in vitro study was carried out in order to investigate the antibiotic release mechanism and the antibacterial properties of commercially (Palacos~® R + G and Palacos~® LV + G) and manually (Palacos~® R + GM and Palacos~® LV + GM) blended gentamicin-loaded bone cements. Samples were characterized by means of scanning electron microscopy (SEM) and compression strength was evaluated. The antibiotic release was investigated by dipping sample in simulated body fluid (SBF) and periodically analyzing the solution by means of high pressure liquid chromatography (HPLC). Different antibacterial tests were performed to investigate the possible influence of blending technique on antibacterial properties. Only some differences were observed between gentamicin manually added and commercial ones, in the release curves, while the antibacterial effect and the mechanical properties seem to not feel the blending technique.

机译：为了研究商用（Palacos®R + G和Palacos®LV + G）和手动（Palacos®R + GM和Palacos®LV）的抗生素释放机理和抗菌性能，进行了体外研究。 + GM）掺有庆大霉素的骨水泥。通过扫描电子显微镜（SEM）表征样品并评估抗压强度。通过将样品浸入模拟体液（SBF）中并定期通过高压液相色谱（HPLC）分析溶液来研究抗生素的释放。进行了不同的抗菌测试，以研究混合技术对抗菌性能的可能影响。手动添加的庆大霉素与市售的庆大霉素之间在释放曲线上仅观察到一些差异，而抗菌效果和机械性能似乎没有感觉到混合技术。

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来源
《Materials science & engineering》 |2013年第5期|3025-3032|共8页
作者
Marta Miola; Alessandro Bistolfi; Maria Carmen Valsania; Carlotta Bianco; Giacomo Fucale; Enrica Verne;
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作者单位

Applied Science and Technology Department, Politecnico di Torino, Italy,Politecnico di Torino, Dipartimento di Scienza Applicata e Tecnologia-DISAT, Corso Duca degli Abruzzi 24,10129 Torino, Italy;

Department of Orthopaedics, Traumatology and HM, University of Turin, Italy,AO CTO, M Adelaide Hospital, Turin, Italy;

Department of Orthopaedics, Traumatology and HM, University of Turin, Italy;

Department of Orthopaedics, Traumatology and HM, University of Turin, Italy;

Chemical, Clinical and Microbiological Analyses Dept,, CTO, Turin, Italy;

Applied Science and Technology Department, Politecnico di Torino, Italy;

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正文语种 eng
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关键词
Antibacterial; Bone cements; Antibiotics; Release;

机译：抗菌;骨水泥;抗生素;释放;

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专利

1. Antibiotic-loaded acrylic bone cements: An in vitro study on the release mechanism and its efficacy [J] . Miola M., Bistolfi A., Valsania M.C., Materials science & engineering, C. Materials for Biogical applications . 2013,第5期

机译：加载抗生素的丙烯酸骨水泥的释放机理及其功效的体外研究
2. Continuous wave ultrasound enhances vancomycin release and antimicrobial efficacy of antibiotic-loaded acrylic bone cement in vitro and in vivo. [J] . Yan S, Cai X, Yan W, Journal of biomedical materials research. Part B, Applied biomaterials. . 2007,第1期

机译：连续波超声可在体外和体内增强万古霉素的释放和抗菌素丙烯酸类骨水泥的抗菌功效。
3. Continuous Wave Ultrasound Enhances Vancomycin Release and Antimicrobial Efficacy of Antibiotic-Loaded Acrylic Bone Cement In Vitro and In Vivo [J] . Shigui Yan, Xunzi Cai, Weiqi Yan Journal of biomedical materials research, Part A . 2007,第1期

机译：连续波超声可增强体内和体外加载抗生素的丙烯酸骨水泥的万古霉素释放和抗菌功效。
4. ATLANTIK Genta, A New Concept Of Gentamicin Loaded HAP/TCP Bone Substitute For Prophylactic Action - In Vitro Releasing Mechanisms Study [C] . A. Bignon, F. Laurent, J. Goldnadel, Bioceramics . 2008

机译：ATLANTIK Genta，庆大霉素负载的HAP / TCP骨替代品的新概念，具有预防作用-体外释放机制研究
5. The bone/cement interface in total hip arthroplasty: An in vitro study of bone surface preparation, fatigue and interface mechanics. [D] . Yang, Dongliang. 2006

机译：全髋关节置换术中的骨/水泥界面：骨表面准备，疲劳和界面力学的体外研究。
6. Isoniazid Could Be Used for Antibiotic-loaded Bone Cement for Musculoskeletal Tuberculosis: An In Vitro Study [O] . Chang Dong Han, Taegwon Oh, Sang-Nae Cho, 2013

机译：异烟肼可用于抗肌肉骨骼结核的骨水泥的体外研究
7. In vitro study of the efficacy of acrylic bone cement loaded with supplementary amounts of gentamicin: Effect on mechanical properties, antibiotic release, and biofilm formation [O] . Dunne, Nicholas, Hill, Janet, McAfee, P., 2007

机译：补充大量庆大霉素的丙烯酸骨水泥功效的体外研究：对机械性能，抗生素释放和生物膜形成的影响

Antibiotic-loaded acrylic bone cements: An in vitro study on the release mechanism and its efficacy

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