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首页> 外文期刊>Materials science & engineering >Multifunctional nanoparticles as photosensitizer delivery carriers for enhanced photodynamic cancer therapy
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Multifunctional nanoparticles as photosensitizer delivery carriers for enhanced photodynamic cancer therapy

机译：多功能纳米粒子作为光敏剂输送载体，用于增强的光动力癌疗法

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摘要

Photodynamic therapy (PDT) is an emerging cancer treatment combining light, oxygen, and a photosensitizer (PS) to produce highly cytotoxic reactive oxygen species that cause cancer cell death. However, most PSs are hydrophobic molecules that have poor water solubility and cannot target tumor tissues, causing damage to normal tissues and cells during PDT. Thus, there is a substantial demand for the development of nanocarrier systems to achieve targeted delivery of PSs into tumor tissues and cells. This review summarizes the research progress in PS delivery systems for PDT treatment of tumors and focuses on the recent design and development of multifunctional nanoparticles as PS delivery carriers for enhanced PDT. These multifunctional nanoparticles possess unique properties, including tunable particle size, changeable shape, stimuli-responsive PS activation, controlled PS release, and hierarchical targeting capability. These properties can increase tumor accumulation, penetration, and cellular internalization of nanoparticles to achieve PS activation and/or release in cancer cells for enhanced PDT. Finally, recent developments in multifunctional nanoparticles for tumor-targeted PS delivery and their future prospects in PDT are discussed.
机译：光动力疗法（PDT）是结合光，氧和光敏剂（PS）的新出现的癌症治疗，以产生引起癌细胞死亡的高细胞毒性反应性氧物质。然而，大多数PSS是疏水分子，其水溶性差，不能靶向肿瘤组织，导致PDT期间对正常组织和细胞造成损伤。因此，存在对纳米载波系统的发展的实质性需求，以实现PSS的靶向递送到肿瘤组织和细胞中。本综述总结了PS递送系统对肿瘤PDT治疗的研究进展，并侧重于近期多功能纳米粒子的设计和开发作为增强PDT的PS输送载体。这些多功能纳米颗粒具有独特的性质，包括可调谐粒度，可变的形状，刺激响应性PS激活，受控PS释放和分级靶向能力。这些性质可以增加纳米颗粒的肿瘤积累，渗透和细胞内化，以获得癌细胞中的PS活化和/或释放以获得增强的PDT。最后，讨论了肿瘤目标PS递送多功能纳米粒子的最新发展及其在PDT中的未来前景。

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  • 来源
    《Materials science & engineering》 |2020年第10期|111099.1-111099.12|共12页
  • 作者

    Zhang Yonghe; Wang Beilei; Zhao Ruibo; Zhang Quan; Kong Xiangdong;

  • 作者单位

    Zhejiang Sci Tech Univ Sch Mat Sci & Engn Key Lab Adv Text Mat & Mfg Technol Minist Educ Hangzhou Peoples R China|Zhejiang Sci Tech Univ Zhejiang Mauritius Joint Res Ctr Biomat & Tissue Hangzhou Peoples R China;

    Zhejiang Sci Tech Univ Coll Life Sci & Med Hangzhou Peoples R China;

    Zhejiang Sci Tech Univ Sch Mat Sci & Engn Key Lab Adv Text Mat & Mfg Technol Minist Educ Hangzhou Peoples R China|Zhejiang Sci Tech Univ Zhejiang Mauritius Joint Res Ctr Biomat & Tissue Hangzhou Peoples R China;

    Zhejiang Sci Tech Univ Sch Mat Sci & Engn Key Lab Adv Text Mat & Mfg Technol Minist Educ Hangzhou Peoples R China|Zhejiang Sci Tech Univ Zhejiang Mauritius Joint Res Ctr Biomat & Tissue Hangzhou Peoples R China;

    Zhejiang Sci Tech Univ Sch Mat Sci & Engn Key Lab Adv Text Mat & Mfg Technol Minist Educ Hangzhou Peoples R China|Zhejiang Sci Tech Univ Zhejiang Mauritius Joint Res Ctr Biomat & Tissue Hangzhou Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Multifunctional nanoparticles; Photodynamic cancer therapy; Photosensitizers; Stimuli-responsive carriers; Targeted delivery;

    机译：多功能纳米粒子;光动力癌疗法;光敏剂;刺激响应载体;有针对性的交付;

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