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首页> 外文期刊>Materials science & engineering >Biomimetic theranostic strategy for anti-metastasis therapy of breast cancer via the macrophage membrane camouflaged superparticles
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Biomimetic theranostic strategy for anti-metastasis therapy of breast cancer via the macrophage membrane camouflaged superparticles

机译：通过巨噬细胞膜伪装超级颗粒乳腺癌抗转移治疗抗转移治疗的生物染色睾丸训练

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摘要

The rational design of theranostic systems are critical for addressing challenging issues associated with cancers. Toward this objective, the multifunctional biomimetic superparticle, termed as DOX-QDs-Lip@M, which can specifically deliver drug to tumor and synergistically monitor their therapeutic effects, was fabricated. Initially, anticancer drug doxorubicin hydrochloride (DOX) and imaging agent quaternary quantum dots (QDs) were loaded into the hydrophilic core region and hydrophobic chamber of liposome by self-assembly method, respectively. The integrated nanostructure can greatly increase the fluorescence intensity of signal unit and tremendously improve the diagnostic sensitivity. Subsequently, the biomimetic DOX-QDs-Lip@M was constructed by fusing and coating the isolated macrophage membranes on the surface of liposome, which can consequently extend the circulation of the whole blood and effectively target the tumor sites. Moreover, the naturally formed biofilm can stabilize the artificial liposome structure, which can prevent the leakage of the loaded materials in the liposome. These integrated properties endow the biomimetic DOX-QDs-Lip@M with improved tumor imaging and anti-metastasis treatment in living systems.
机译：治疗系统的理性设计对于解决与癌症相关的具有挑战性的问题至关重要。朝向该目标，多功能仿生超级粒子称为DOX-QDS-LIP @ M，其可以专门向肿瘤递送药物并协同监测其治疗效果。最初，通过自组装方法将盐酸盐酸盐（DOX）和成像剂季磅量子点（QDS）加载到亲水核心区和脂质体的疏水性室中。集成的纳米结构可以大大增加信号单元的荧光强度，并极大地提高诊断敏感性。随后，通过熔化和涂覆在脂质体表面上的分离的巨噬细胞膜来构建生物菊素DOX-QDS-唇缘@ M，因此可以延长全血的循环并有效地靶向肿瘤部位。此外，天然形成的生物膜可以稳定人工脂质体结构，这可以防止装载材料在脂质体中的泄漏。这些综合性质赋予生物菊素DOX-QDS-LIP @ M，具有改善的肿瘤成像和活生植物中的抗转移处理。

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  • 来源
    《Materials science & engineering》 |2020年第10期|111097.1-111097.9|共9页
  • 作者

    Liang Binbin; Deng Tao; Li Jinping; Ouyang Xueliang; Na Weidan; Deng Dawei;

  • 作者单位

    China Pharmaceut Univ Sch Engn Dept Pharmaceut Engn Nanjing 211198 Peoples R China|China Pharmaceut Univ Sch Engn Dept Biomed Engn Nanjing 211198 Peoples R China;

    Chongqing Med Univ Coll Pharm Dept Pharmaceut Chongqing 400016 Peoples R China;

    China Pharmaceut Univ Sch Engn Dept Pharmaceut Engn Nanjing 211198 Peoples R China|China Pharmaceut Univ Sch Engn Dept Biomed Engn Nanjing 211198 Peoples R China;

    China Pharmaceut Univ Sch Engn Dept Pharmaceut Engn Nanjing 211198 Peoples R China|China Pharmaceut Univ Sch Engn Dept Biomed Engn Nanjing 211198 Peoples R China;

    China Pharmaceut Univ Sch Engn Dept Pharmaceut Engn Nanjing 211198 Peoples R China|China Pharmaceut Univ Sch Engn Dept Biomed Engn Nanjing 211198 Peoples R China;

    China Pharmaceut Univ Sch Engn Dept Pharmaceut Engn Nanjing 211198 Peoples R China|China Pharmaceut Univ Sch Engn Dept Biomed Engn Nanjing 211198 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Cancer metastasis; Theranostic; Liposome; Macrophage membrane; Quantum dots;

    机译：癌症转移;Theranostic;脂质体;巨噬细胞膜;量子点;

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