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首页> 外文期刊>Materials science & engineering >A potential strategy for in-stent restenosis: Inhibition of migration and proliferation of vascular smooth muscle cells by Cu ion
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A potential strategy for in-stent restenosis: Inhibition of migration and proliferation of vascular smooth muscle cells by Cu ion

机译：支架内再狭窄的潜在策略：Cu离子抑制血管平滑肌细胞的迁移和增殖

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摘要

The in-stent restenosis (ISR) often happens after the implantation of metal stents, including both bare metal stents (BMSs) and drug-eluting stents (DESs). Drug release from DESs could reduce significantly the occurrence of ISR but also suppress the revascularization and cause thrombosis. In this study, the effect of Cu ion in a range of 0 to 500 mu M on the migration and proliferation of rat aortic smooth muscle cells (RASMCs) was investigated by a series of in vitro experiments including wound-healing assay, cell viability assay and flow cytometric analysis. It has been found that the critical concentration of Cu ion should be at least 250 mu M in order to significantly inhibit the migration of RASMCs and the proliferation of RASMCs were impeded by every dose of Cu ion used in this study. In addition, the protein level of caspase-3 was upregulated by 250 mu M and 500 mu M Cu2+ exposure, which might be the main reason for RASMCs apoptosis. Thus, it is proposed that ISR might be prevented by the constant release of Cu ion.
机译：支架内恢复（ISR）经常发生在植入金属支架之后，包括裸金属支架（BMS）和药物洗脱支架（DESS）。来自DES的药物释放可以显着降低ISR的发生，但也抑制了血运重建并引起血栓形成。在该研究中，通过一系列体外实验研究了大鼠主动脉平滑肌细胞（Rasmcs）的迁移和增殖范围内Cu离子在0至500μm的范围内的影响，包括伤口愈合测定，细胞活力测定和流式细胞术分析。已经发现，Cu离子的临界浓度应至少为250μm，以显着抑制Rasmc的迁移，并且通过本研究中使用的每种剂量的Cu离子阻抗Rasmc的增殖。此外，Caspase-3的蛋白质水平通过250μm和500μmcu2 +曝光来上调，这可能是Rasmcs凋亡的主要原因。因此，提出可以通过Cu离子的恒定释放来防止ISR。

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  • 来源
    《Materials science & engineering》 |2020年第10期|111090.1-111090.6|共6页
  • 作者

    Zhang Yuan; Wang Xiaoyan; Ma Zhiling; Bai Bing; Liu Jie; Yang Lei; Qin Gaowu; Zhang Erlin;

  • 作者单位

    Northeastern Univ Sch Mat Sci & Engn Key Lab Anisotropy & Texture Mat Educ Minist China Shenyang 110819 Peoples R China;

    Northeastern Univ Sch Met Shenyang 110819 Peoples R China;

    Jiamusi Univ Sch Mat Sci & Engn Jiamusi 154007 Peoples R China;

    China Med Univ Sch Stomatol Dept Prosthodont Shenyang 110001 Liaoning Peoples R China;

    Jiamusi Univ Sch Mat Sci & Engn Jiamusi 154007 Peoples R China;

    Northeastern Univ Sch Mat Sci & Engn Key Lab Anisotropy & Texture Mat Educ Minist China Shenyang 110819 Peoples R China;

    Northeastern Univ Sch Mat Sci & Engn Key Lab Anisotropy & Texture Mat Educ Minist China Shenyang 110819 Peoples R China;

    Northeastern Univ Sch Mat Sci & Engn Key Lab Anisotropy & Texture Mat Educ Minist China Shenyang 110819 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    In-stent restenosis (ISR); Migration; Proliferation; Rat aortic smooth muscle cells (RASMCs);

    机译：支架再狭窄（ISR）;迁移;增殖;大鼠主动脉平滑肌细胞（Rasmc）;

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