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首页> 外文期刊>Materials science & engineering >Antibacterial alginateano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity
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Antibacterial alginateano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity

机译：骨组织工程抗菌藻酸盐/纳米羟基磷灰石复合材料：评估其生物活性，生物相容性和抗菌活性

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Bone substitute materials based on bioceramics and polymers have evolved shifting from a passive role where they are merely accepted by the body; to an active role, where they respond to particular environmental conditions or to different types of cues generating suitable integration (osseointegration for this case) inside the host tissue. In this work, two types of composite materials based on a bioceramic (synthetic nano-hydroxyapatite, HA) and a biopolymer (sodium alginate, ALG) have been designed and assessed for promoting the bone regeneration. These materials were loaded with ciprofloxacin (CIP) for obtaining, not only a suitable material for a filling but with antibacterial properties. Therefore, their main features were studied through Fourier transformed-infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron microscopy (TEM). Ultraviolet-Visible (UV-Vis) spectroscopy was used for obtaining the released concentrations of CIP and Zeta-potential (zeta-potential) was used for characterizing the adsorption of CIP onto nanoparticles. The release profile of this drug has been fit with the Ritger-Peppas model, used for studying the release kinetics of hydrogel-based systems. The bioactivity of these composites was also evaluated after 30 days of incubation in a simulated body fluid solution (SBF). Then, the assessment of antibacterial capability against the three main strains cause osteomyelitis was performed. Finally, the cell viability study and the cellular morphology assay were also carried out. These last assays have shown encouraging results and, gathered with their other properties, such as their bioactivity and antibacterial properties; they could lead to propose these materials as new bone filler antibiotic devices.
机译：基于生物陶瓷和聚合物的骨替代材料已经从被动作用中演变的转移，在那里它们仅由身体接受;在积极的作用中，它们在宿主组织内响应特定的环境条件或产生合适的积分（对于这种情况下的骨整合）的不同类型的提示。在这项工作中，已经设计并评估了基于生物陶瓷（合成纳米羟基磷灰石，HA）和生物聚合物（藻酸钠，藻酸钠）的两种类型的复合材料，以促进骨再生。将这些材料用环氟苯甲酰辛（CIP）加载，不仅可以获得合适的填充材料，而且具有抗菌性质。因此，通过傅里叶变换 - 红外光谱（FT-IR），X射线衍射（XRD）和透射电子显微镜（TEM）研究了它们的主要特征。可见紫外 - 可见（UV-VIS）光谱法用于获得释放的CIP和Zeta-Posity（Zeta-电位）用于表征CIP对纳米颗粒的吸附。该药物的释放曲线与Ritger-Peppas模型适合，用于研究水凝胶基系统的释放动力学。在模拟体液溶液（SBF）的温育30天后，还评估这些复合材料的生物活性。然后，对三种主要菌株的抗菌性评估引起骨髓炎的抗菌性能力。最后，还进行了细胞活力研究和细胞形态测定。这些最后的测定表明，令人鼓舞的结果，并聚集在其他性质，例如它们的生物活性和抗菌性质;他们可能导致这些材料作为新的骨填充抗生素装置。

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