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首页> 外文期刊>Materials science & engineering >Construction and performance evaluation of a sustained release implant material polyetheretherketone with antibacterial properties
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Construction and performance evaluation of a sustained release implant material polyetheretherketone with antibacterial properties

机译：抗菌性能持续释放植入物质聚醚醚酮的构建与性能评价

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Objective: This study aimed to construct a tightly binding antibiotic sustained release system on the polyetheretherketone (PEEK) surface and investigate the cellular activity and antibacterial properties of the new oral implant materials.& nbsp; Methods: Low-temperature argon plasma under certain parameters was used to prepare P-PEEK with nanotopology, and chemical deposition technology was adopted to form a polydopamine (PDA) coating on the PEEK surface to build a biological binding platform, PDA/P-PEEK. Subsequently, vancomycin gelatin nanoparticles (Van-GNPs) were prepared by two-step desolvation method. Finally, Van-GNPs were combined with PEEK implant material surface to form a new composite material, Van-GNPs/PEEK. scanning electron microscope (SEM), atomic force microscope (AFM), energy dispersive spectrometer (EDS), and contact angle tester were used to comprehensively characterize the materials. The in vitro release test of Van was performed by dynamic dialysis with ultraviolet spectrophotometer. The cell cytotoxicity and adhesion tests were studied by mouse embryonic osteoblasts. The antibacterial properties were evaluated by bacterial adhesion test, plate colony counting, and antimicrobial ring test with Staphylococcus aureus and Streptococcus mutans.& nbsp; Results: PEEK was treated with low-temperature argon plasma and attached to PDA to form a biological binding platform. The synthesized Van-GNPs were smooth, round, with uniform particle size distribution, and bound to PEEK to form a new composite material, which can release Van constantly. Cell experiments showed that VanGNPs/PEEK had no cytotoxicity and had good interaction with osteoblasts. Bacterial experiments showed that surface conjugation with Van-GNPs could significantly improve the antibacterial performance of PEEK against S. aureus and S. mutans.& nbsp; & nbsp;Significance: This study demonstrated that Van-GNPs/PEEK have good cellular compatibility and autonomous antibacterial properties, which provide a theoretical basis for the wide application of PEEK in the field of stomatology.
机译：目的：本研究旨在在聚醚醚酮（PEEK）表面上构建紧密结合的抗生素缓释系统，并研究新口腔植入物材料的细胞活性和抗菌性能。＆NBSP;方法：使用低温氩等离子体在某些参数下用纳米音阶机制制备P-PEEK，采用化学沉积技术在PEEK地表上形成多胺（PDA）涂层，以构建生物结合平台，PDA / P-PEEK 。随后，通过两步去溶剂化方法制备万古霉素明胶纳米颗粒（VAN-GNP）。最后，van-GNP与PEEK植入物材料表面相结合，形成新的复合材料，van-GNPS / PEEK。扫描电子显微镜（SEM），原子力显微镜（AFM），能量分散光谱仪（EDS）和接触角测试仪用于全面表征材料。用紫外分光光度计通过动态透析进行面包车的体外释放试验。通过小鼠胚胎成骨细胞研究细胞细胞毒性和粘附试验。通过细菌粘附试验，板群计数和抗微生物环试验评价抗菌性能，与金黄色葡萄球菌和链球菌异常。＆NBSP;结果：PEEK用低温氩等离子体处理，并附在PDA上以形成生物结合平台。合成的van-GNPS光滑，圆形，颗粒尺寸分布均匀，并束缚形成新的复合材料，可持续释放面包车。细胞实验表明，Vangnps / PEEK没有细胞毒性，与成骨细胞有良好的相互作用。细菌实验表明，与van-GNPS的表面缀合可以显着改善PEEK对抗金黄色葡萄球菌和S. mutans的抗菌性能。＆nbsp; ＆NBSP;意义：本研究表明，van-GNPS / PEEK具有良好的细胞相容性和自主抗菌性能，为PEEK在口腔学领域提供了一种理论依据。

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