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首页> 外文期刊>Materials science & engineering >Hyaluronic acid hydrogels reinforced with laser spun bioactive glass micro-and nanofibres doped with lithium
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Hyaluronic acid hydrogels reinforced with laser spun bioactive glass micro-and nanofibres doped with lithium

机译：透明质酸水凝胶加强了激光纺生物活性玻璃微纤维和纳米纤维掺杂锂锂

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摘要

The repair of articular cartilage lesions in weight-bearing joints remains as a significant challenge due to the low regenerative capacity of this tissue. Hydrogels are candidates to repair lesions as they have similar properties to cartilage extracellular matrix but they are unable to meet the mechanical and biological requirements for a successful outcome. Here, we reinforce hyaluronic acid (HA) hydrogels with 13-93-lithium bioactive glass microand nanofibres produced by laser spinning. The glass fibres are a reinforcement filler and a platform for the delivery of therapeutic lithium-ions. The elastic modulus of the composites is more than three times higher than in HA hydrogels. Modelling of the reinforcement corroborates the experimental results. ATDC5 chondrogenic cells seeded on the composites are viable and more proliferation occurs on the hydrogels containing fibres than in HA hydrogels alone. Furthermore, the chondrogenic behavior on HA constructs with fibres containing lithium is more marked than in hydrogels with no-lithium fibres.
机译：由于该组织的低再生能力，负重关节中关节式软骨病变的修复仍然是一个重大挑战。水凝胶是修复病变的候选物，因为它们对软骨细胞外基质具有相似的性质，但它们无法满足成功结果的机械和生物要求。这里，通过激光纺丝产生13-93-锂生物活性玻璃微安纳米纤维的透明质酸（HA）水凝胶加固。玻璃纤维是增强填料和用于递送治疗锂离子的平台。复合材料的弹性模量比HA水凝胶高三倍。钢筋建模证实了实验结果。在复合材料上播种的ATDC5软骨内细胞是可行的，并且在含有纤维的水凝胶上发生更多的增殖，而不是单独的HA水凝胶。此外，含有锂的纤维的HA构建体的软骨制性行为比用无锂纤维的水凝胶更标记。

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  • 来源
    《Materials science & engineering》 |2021年第7期|112124.1-112124.12|共12页
  • 作者

    Riveiro Antonio; Amorim Sara; Solanki Anu; Costa Diana S.; Pires Ricardo A.; Quintero Felix; del Val Jesus; Comesana Rafael; Badaoui Aida; Lusquinos Fernando; Macon Anthony L. B.; Tallia Francesca; Jones Julian R.; Reis Rui L.; Pou Juan;

  • 作者单位

    Univ Vigo Mat Engn Appl Mech & Construct Dept EEI Vigo 36310 Spain;

    Univ Minho I3Bs Res Inst Biomat Biodegradables & Biomat 3Bs Res Grp Headquarters European Inst Excellence Tissue Engn AvePk Parque Ciencia Tecnol Zona Ind Gandra P-4805017 Barco Guimaraes Portugal|ICVS 3Bs PT Govt Associate Lab P-4805017 Braga Portugal|Headquarters Univ Minho Discoveries Ctr Regenerat & Precis Med Avepk P-4805017 Barco Guimaraes Portugal;

    Imperial Coll London Dept Mat South Kensington Campus London SW7 2AZ England;

    Univ Minho I3Bs Res Inst Biomat Biodegradables & Biomat 3Bs Res Grp Headquarters European Inst Excellence Tissue Engn AvePk Parque Ciencia Tecnol Zona Ind Gandra P-4805017 Barco Guimaraes Portugal|ICVS 3Bs PT Govt Associate Lab P-4805017 Braga Portugal;

    Univ Minho I3Bs Res Inst Biomat Biodegradables & Biomat 3Bs Res Grp Headquarters European Inst Excellence Tissue Engn AvePk Parque Ciencia Tecnol Zona Ind Gandra P-4805017 Barco Guimaraes Portugal|ICVS 3Bs PT Govt Associate Lab P-4805017 Braga Portugal|Headquarters Univ Minho Discoveries Ctr Regenerat & Precis Med Avepk P-4805017 Barco Guimaraes Portugal;

    Univ Vigo Dept Appl Phys EEI Vigo 36310 Spain;

    Univ Vigo Dept Appl Phys EEI Vigo 36310 Spain;

    Univ Vigo Mat Engn Appl Mech & Construct Dept EEI Vigo 36310 Spain;

    Univ Vigo Mat Engn Appl Mech & Construct Dept EEI Vigo 36310 Spain;

    Univ Vigo Dept Appl Phys EEI Vigo 36310 Spain;

    Imperial Coll London Dept Mat South Kensington Campus London SW7 2AZ England;

    Imperial Coll London Dept Mat South Kensington Campus London SW7 2AZ England;

    Imperial Coll London Dept Mat South Kensington Campus London SW7 2AZ England;

    Univ Minho I3Bs Res Inst Biomat Biodegradables & Biomat 3Bs Res Grp Headquarters European Inst Excellence Tissue Engn AvePk Parque Ciencia Tecnol Zona Ind Gandra P-4805017 Barco Guimaraes Portugal|ICVS 3Bs PT Govt Associate Lab P-4805017 Braga Portugal|Headquarters Univ Minho Discoveries Ctr Regenerat & Precis Med Avepk P-4805017 Barco Guimaraes Portugal;

    Univ Vigo Dept Appl Phys EEI Vigo 36310 Spain;

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  • 正文语种 eng
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  • 关键词

    Laser spinning; Hyaluronic acid; Hydrogel; Bioactive glass; Lithium;

    机译：激光纺丝;透明质酸;水凝胶;生物活性玻璃;锂;

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