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首页> 外文期刊>RSC Advances >Synthesis of hyaluronic acid hydrogels by crosslinking the mixture of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid with 1,4-butanediol diglycidyl ether
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Synthesis of hyaluronic acid hydrogels by crosslinking the mixture of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid with 1,4-butanediol diglycidyl ether

机译：用1,4-丁二醇二缩水甘油醚交联透明质酸水凝胶的合成透明质酸水凝胶

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摘要

High molecular weight hyaluronic acid (HMW-HA) and low molecular weight hyaluronic acid (LMW-HA) were mixed at different ratios and cross-linked with 1,4-butanediol diglycidyl ether (BDDE) to prepare five hyaluronic acid hydrogels A-E. Enzymolysis stability, swelling rate, crosslinking degree, rheological characteristics, BDDE residual rate, surface microstructure, and cytotoxicity of different hydrogels were investigated. The results showed that hydrogel B obtained by 10% HA (w/v, HMW-HA and LMW-HA having a mass ratio of 4 : 1) crosslinking with 1% BDDE (v/v) had stronger in vitro anti-degradation ability, better mechanical properties and lower cytotoxicity than those prepared by mixing in different proportions. Hydrogel B has potential applications in regenerative medicine and tissue engineering.
机译：将高分子量透明质酸（HMW-HA）和低分子量透明质酸（LMW-HA）以不同的比例混合并与1,4-丁二醇二缩水甘油醚（BDDE）交联以制备五个透明质酸水凝胶A-E。 研究了酶解稳定性，溶胀率，交联度，流变学特征，BDDE残留率，表面微观结构和不同水凝胶的细胞毒性。 结果表明，用1％BDDE（v / v）与1％BDDE（v / v）交联的10％HA（w / v，hmw-ha和lmw-ha）的水凝胶B具有更强的体外抗降解能力 ，更好的机械性能和低细胞毒性而不是通过在不同比例中混合制备的那些。 水凝胶B具有再生医学和组织工程的潜在应用。

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  • 来源
    《RSC Advances》 |2020年第12期|共8页
  • 作者

    Xue Yu; Chen Hongyue; Xu Chao; Yu Dinghua; Xu Huajin; Hu Yi;

  • 作者单位

    Nanjing Tech Univ Sch Pharmaceut Sci State Key Lab Mat Oriented Chem Engn Nanjing 210009 Peoples R China;

    Nanjing Tech Univ Sch Pharmaceut Sci State Key Lab Mat Oriented Chem Engn Nanjing 210009 Peoples R China;

    Nanjing Tech Univ Sch Pharmaceut Sci State Key Lab Mat Oriented Chem Engn Nanjing 210009 Peoples R China;

    Nanjing Tech Univ Sch Pharmaceut Sci State Key Lab Mat Oriented Chem Engn Nanjing 210009 Peoples R China;

    Nanjing Tech Univ Sch Pharmaceut Sci State Key Lab Mat Oriented Chem Engn Nanjing 210009 Peoples R China;

    Nanjing Tech Univ Sch Pharmaceut Sci State Key Lab Mat Oriented Chem Engn Nanjing 210009 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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