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Synthesis of hierarchical and flower-like TiO_2 nanowire microspheres as biocompatible cell carriers

机译：作为生物相容性细胞载体的分层和花样TiO_2纳米线微球的合成

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摘要

Fibrous materials are of great interest in the development of tissue regenerative matrix. However, synthesis of inorganic fibrous microspheres as cell carriers is a great challenge. In this study, we for the first time report on the synthesis of novel hierarchical and flower-like TiO2 nanowire (NW) microspheres as biocompatible cell carriers. TiO2 NW microspheres were synthesized through in situ alkali hydrothermal treatment of the TiO2 nanoparticle (NP) microspheres and their microstructure, formation mechanism and in vitro biocompatibility were evaluated. SEM observations show that the resulting TiO2 NW microspheres were constructed by a large number of NWs with the diameter of 10-20 nm and exhibited a flower-like and hierarchical morphology with the diameter of 400-600 mu m. XRD patterns indicate that TiO2 NW microspheres were constructed by both rutile and anatase phase of TiO2. FT-IR spectra reveal that Ti-O-Ti bonds were involved in TiO2 NW microspheres. In vitro biocompatibility was evaluated by seeding the fibroblast L929 cells on the microspheres. A conventional MTT assay quantitatively indicates that the TiO2 NW microspheres favored adhesion and proliferation of cells and were biocompatible, while SEM observations qualitatively confirmed that the cells were well grown on the surface of TiO2 NW microspheres. Thus, the as-synthesized TiO2 NW microspheres would be applicable to novel and biocompatible cell carriers.
机译：纤维材料对组织再生基质的发展具有很大的兴趣。然而，作为细胞载体的无机纤维微球的合成是一个很大的挑战。在这项研究中，我们首次报告了新型等级和花样TiO2纳米线（NW）微球作为生物相容性细胞载体的合成。通过原位碱水热处理TiO2纳米颗粒（NP）微球合成TiO 2 NW微球，评价其微观结构，形成机理和体外生物相容性。 SEM观察结果表明，得到的TiO 2 NW微球由大量的直径为10-20nm的NW构成，并且表现出具有400-600μm的直径的花样和分层形态。 XRD图案表明TiO2 NW微球由金红石和TiO 2的锐钛矿相构成。 FT-IR光谱显示Ti-O-Ti键参与TiO2 NW微球。通过在微球上播种成纤维细胞L929细胞来评价体外生物相容性。传统的MTT测定定量表明TiO 2 NW微球的粘附性和细胞的粘附性和增殖并且是生物相容性的，而SEM观察定性证实细胞在TiO 2 NW微球表面上良好地生长。因此，AS合成的TiO2 NW微球可适用于新型和生物相容性细胞载体。

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