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首页> 外文期刊>Materials science & engineering >Experimental resin-modified calcium-silicate cement containing N-(2-hydroxyethyl) acrylamide monomer for pulp tissue engineering
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Experimental resin-modified calcium-silicate cement containing N-(2-hydroxyethyl) acrylamide monomer for pulp tissue engineering

机译：含有N-（2-羟乙基）丙烯酰胺单体的实验树脂改性钙硅酸盐水泥，用于纸浆组织工程

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摘要

Aim: Our study aimed to measure (1) the flexural strength, (2) shear bond strength to dentin, (3) pH, and (4) calcium (Ca) release of a series of innovative resin-modified calcium-silicate pulp-capping cements (Rm-CSCs). Using an ex-vivo human vital tooth-culture model, we additionally assessed (5) their pulp-healing initiation when brought in direct contact with human dental pulp tissue. Methodology: Three experimental Rm-CSCs, being referred to 'Exp_HEAA', 'Exp_GDM' and 'Exp_HEAA/GDM', contained either 20 wt% N-(2-hydroxyethyl) acrylamide (HEAA), 20 wt% glycerol dimethacrylate (GDM) or 10 wt% HEAA plus 10 wt% GDM, added to a common base composition consisting of 25 wt% urethane dimethacrylate (UDMA), 10 wt% 4-methacryloxyethyl trimellitate anhydride (4-MET), and 5 wt% N,N'-{[(2-acrylamido2-[(3-acrylamidopropoxy)methyl] propane-1,3-diyl)bis(oxy)]bis-(propane-1,3-diyl)}diacrylamide (FAM-401). As Ca source and radiopacifier, 37 wt% tricalcium silicate powder (TCS) and 3 wt% zirconium oxide (ZrO 2) were respectively added. Results: All three experimental Rm-CSCs revealed a significantly higher flexural strength and shear bond strength to dentin (p 0.05) than the commercial reference Rm-CSC TheraCal LC (Bisco). Exp_HEAA presented with a significantly higher Ca release and pH at 24 h compared with the other Rm-CSCs (p 0.05). At 1 week, the Ca release and pH of Exp_HEAA and Exp_HEAA/GDM was significantly higher than those of Exp_GDM and TheraCal LC (p 0.05). Using the ex-vivo human vital tooth culture model, Exp_HEAA revealed pulp-healing initiation capacity as documented by nestin and collagen-I expression. Conclusions: Depending on the formulation, the innovative Rm-CSCs performed favorably for primary properties of relevance regarding pulp capping, this more specifically in terms of flexural strength, bond strength to dentin, as well as alkaline pH and Ca release. However, only Exp_HEAA revealed pulp-healing initiation in direct contact with human dental pulp tissue in the ex-vivo human vital tooth-culture model. This promising outcome for Exp_HEAA should be attributed to the combined use of (1) a novel hydrophilic acrylamide monomer, enabling sufficient polymerization while maintaining adequate hydrophilicity, with (2) the functional monomer 4-MET, possessing chemical bonding potential to dentin, and (3) tricalcium silicate powder to achieve an alkaline pH and to release Ca in a sufficient and controlled way.
机译：目的：我们的研究旨在测量（1）弯曲强度，（2）剪切粘合强度至牙本质，（3）pH和（4）钙（CA）释放一系列创新的树脂改性钙硅酸盐浆 - 覆盖水泥（RM-CSC）。使用前体内人的重要牙齿培养模型，我们另外评估（5）与人牙髓组织直接接触时的纸浆愈合开始。方法论：三种实验RM-CSCs，称为'Exp_heaa'，'Exp_GDM'和'Exp_heaa / Gdm'，含有20wt％N-（2-羟乙基）丙烯酰胺（HEAA），20wt％甘油二甲基丙烯酸酯（GDM）或者10wt％HEAA加10wt％GDM，加入由25wt％氨基甲酸酯二甲基丙烯酸酯（UDMA），10wt％4-甲基丙烯酰甲氧基乙基酸酐（4-Met）和5wt％n，n'中的共同基础组合物中加入到共氨基组合物中。 - {[（2-丙基酰胺酰胺氧基）甲基]丙烷-1,3-二基）双（氧）]双（丙烷-1,3-二基）}二蛋白（FAM-401）。作为Ca源和射线处理器，分别加入37wt％硅酸钙粉末（Tcs）和3wt％氧化锆（ZrO 2）。结果：所有三种实验RM-CSCS均明显较高的弯曲强度和剪切粘合强度，比商业参考RM-CSC治疗LC（BISCO）对牙本质（P <0.05）显示出明显更高的弯曲强度和剪切粘合强度。与其他RM-CSCs相比，EXP_HEAA在24小时内呈现显着更高的Ca释放和pH（P <0.05）。在1周，Ca释放和Exp_heaa和Exp_heaa / gdm的pH值明显高于Exp_GDM和Theracal LC（P <0.05）。使用前体内人的重要牙齿培养模型，EXP_HEAA揭示了Nestin和Collagen-I表达所记录的纸浆愈合起始能力。结论：取决于配方，创新的RM-CSCS对于纸浆封端的相关性的主要特性有利地表演，这更具体地就弯曲强度而言，粘合强度与牙本质，以及碱性pH和Ca释放。然而，只有Exp_heaa揭示了与人类生命牙齿培养模型中的人牙髓组织直接接触的纸浆愈合开始。 exp_heaa的这一有希望的结果应归因于（1）新的亲水性丙烯酰胺单体的合并使用，使得能够在保持足够的亲水性同时进行足够的聚合，其中（2）具有与牙本质的功能性单体4-met，具有化学粘合潜力，并且（ 3）硅酸钙粉末以获得碱性pH并以充分且受控的方式释放CA。

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  • 来源
    《Materials science & engineering》 |2021年第7期|112105.1-112105.11|共11页
  • 作者

    Pedano Mariano S.; Yoshihara Kumiko; Li Xin; Camargo Bernardo; Van Landuyt Kirsten; Meerbeek Bart Van;

  • 作者单位

    KU Leuven Univ Leuven Dept Oral Hlth Sci BIOMAT Biomat Res Grp Leuven Belgium|UZ Leuven Univ Hosp Leuven Leuven Belgium;

    Natl Inst Adv Ind Sci & Technol Hlth Res Inst 2217-14 Hayashi Cho Takamaysu Kagawa 7610395 Japan|Okayama Univ Grad Sch Med Dent & Pharmaceut Sci Dept Pathol & Expt Med 2-5-1 Shikata Cho Okayama 7008558 Japan;

    KU Leuven Univ Leuven Dept Oral Hlth Sci BIOMAT Biomat Res Grp Leuven Belgium|UZ Leuven Univ Hosp Leuven Leuven Belgium;

    KU Leuven Univ Leuven Dept Oral Hlth Sci BIOMAT Biomat Res Grp Leuven Belgium|UZ Leuven Univ Hosp Leuven Leuven Belgium;

    KU Leuven Univ Leuven Dept Oral Hlth Sci BIOMAT Biomat Res Grp Leuven Belgium|UZ Leuven Univ Hosp Leuven Leuven Belgium;

    KU Leuven Univ Leuven Dept Oral Hlth Sci BIOMAT Biomat Res Grp Leuven Belgium|UZ Leuven Univ Hosp Leuven Leuven Belgium;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Bioceramics; Human vital tooth-culture model; Micro-CT; Vital pulp therapy; Endodontics; Pulp tissue repair;

    机译：生物陶瓷;人类生命牙齿培养模型;微型CT;重要的纸浆疗法;牙髓组织修复;

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