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Spatially and temporally controlled hydrogels for tissue engineering

机译:用于组织工程的时空控制水凝胶

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摘要

Recent years have seen tremendous advances in the field of hydrogel-based biomaterials. One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels’ properties and functions. Here, we critically review the emerging progress of spatiotemporal control over biomaterial properties towards the development of functional engineered tissue constructs. Specifically, we will highlight the main advances in the spatial control of biomaterials, such as surface modification, microfabrication, photo-patterning, and bioprinting, as well as advances in the temporal control of biomaterials, such as controlled release of molecules, photocleaving of proteins, and controlled hydrogel degradation. We believe that the development and integration of these techniques will drive the evolution of next-generation engineered tissues.
机译:近年来,在基于水凝胶的生物材料领域已经取得了巨大的进步。该领域最重要的革命之一是元素或技术的集成,这些元素或技术可以对水凝胶的特性和功能进行时空控制。在这里,我们批判性地回顾了时空控制生物材料特性朝着功能工程组织构造发展的新进展。具体来说,我们将重点介绍生物材料在空间控制方面的主要进展,例如表面修饰,微加工,光图案化和生物印刷,以及生物材料在时间控制方面的进展,例如分子的受控释放,蛋白质的光裂解。 ,并控制水凝胶降解。我们相信,这些技术的发展和整合将推动下一代工程组织的发展。

著录项

  • 来源
    《Materials Science & Engineering》 |2017年第9期|1-35|共35页
  • 作者单位

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States,Department of Developmental BioEngineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, Netherlands;

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States,Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea;

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States;

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States,Microsystems Technologies Laboratories, MIT, Cambridge, MA, United States,Centro de Biotecnología-FEMSA, Tecnologico de Monterrey, Monterrey, Nuevo León, Mexico;

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States;

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States;

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States;

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States;

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States,Department of Chemical Engineering, Henry M. Rowan School of Engineering, Rowan University, Glassboro, NJ, United States;

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States,Microsystems Technologies Laboratories, MIT, Cambridge, MA, United States,Centro de Biotecnología-FEMSA, Tecnologico de Monterrey, Monterrey, Nuevo León, Mexico;

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States;

    Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, United States,Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, United States,Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul, South Korea,Department of Physics, King Abdulaziz University, Jeddah, Saudi Arabia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Biomaterials; Bioprinting; Cell-biomaterial interaction; Cellular microenvironments; Hydrogel; Microfabrication; Tissue engineering;

    机译:生物材料;生物印刷;细胞-生物材料相互作用;细胞微环境;水凝胶;微细加工;组织工程;

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