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Handling Parameter Variations during the Treatment of Type 1 Diabetes Mellitus: In Silico Results

机译:处理1型糖尿病患者期间的参数变异:在硅效果中

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摘要

Type 1 diabetic patients need a strict treatment to regulate blood glucose concentration in a target range. Despite the development of different control strategies, the model parameter variations, given by physiological changes, can generate an inaccurate treatment and in consequence hyperglycemia and hypoglycemia episodes. Therefore, it is necessary to use control techniques that compensate such effects and maintain the control goals. Here, the effect of parametric variations is examined by the sensitivity analysis from which the most influential parameters in glycemia dynamics are detected. Based on that, an offset-free MPC strategy for impulsive systems is given for the first time in literature and simulated for type 1 diabetes treatment. This scheme along with the impulsive zone MPC with artificial variables reestablishes the normoglycemia behavior since the parameter variations are adequately rejected. However, only parametric variations up to 50% from their nominal values are well compensated, which suggests that more robust formulations are needed to ensure a greater rejection of physiological variations.
机译:1型糖尿病患者需要严格治疗,以调节靶范围内的血糖浓度。尽管发展不同的控制策略,但通过生理变化给出的模型参数变异,可以产生不准确的治疗和后果血糖和低血糖发作。因此,必须使用控制技术来补偿等效果并维持控制目标。这里,通过检测到糖血症动力学中最有影响力的参数的敏感性分析来检查参数变异的效果。基于此,对脉冲系统的无偏移MPC策略是第一次文献中的第一次和模拟1型糖尿病治疗。该方案与具有人工变量的冲动区MPC一起重新建立常规血糖行为,因为参数变化被充分拒绝。然而,只有高达50%的总条变化均得到很好的补偿,这表明需要更稳健的配方来确保更加抑制生理变化。

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  • 来源
    《Mathematical Problems in Engineering》 |2019年第12期|2640405.1-2640405.21|共21页
  • 作者单位

    Univ Nacl Colombia Fac Minas Grp GITA Cra 80 65-223 Medellin Colombia;

    Univ Nacl Colombia Fac Minas Grp GITA Cra 80 65-223 Medellin Colombia;

    Univ Nacl Colombia Fac Minas Grp GITA Cra 80 65-223 Medellin Colombia|Consejo Nacl Invest Cient & Tecn Inst Desarrollo Tecnol Ind Quim INTEC RA-3000 Santa Fe Argentina;

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