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首页> 外文期刊>Mechatronics, IEEE/ASME Transactions on >A Soft Magnetic Core can Enhance Navigation Performance of Magnetic Nanoparticles in Targeted Drug Delivery
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A Soft Magnetic Core can Enhance Navigation Performance of Magnetic Nanoparticles in Targeted Drug Delivery

机译：软磁芯可以增强靶向药物输送中磁性纳米颗粒的导航性能

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摘要

Magnetic nanoparticles (MNPs) are a promising candidate for use as carriers in drug delivery systems. A navigation system with real-time actuation and monitoring of MNPs is inevitably required for more precise targeting and diagnosis. In this paper, we propose a novel electromagnetic navigation system with a coil combined with a soft magnetic core. This system can be used for magnetic particle imaging (MPI) and electromagnetic actuator functions with a higher steering force and enhanced monitoring resolution. A soft magnetic core with coils can increase the magnetic gradient field. However, this also generates harmonic noise, which makes it difficult to acquire MNP monitoring signals with MPI. Therefore, the use of amplitude modulation magnetic particle imaging (AM MPI) is suggested. AM MPI uses a low-amplitude excitation field combined with a low-frequency drive field. Using this system, the measured signal becomes less sensitive to the soft magnetic core. Based on the new MPI scheme and the combination of the coil with the magnetic cores, the proposed navigation system can implement one-dimensional (1-D) MNP navigation and 2-D MPI. The proposed navigation system can shorten the 1-D guidance time by about 25% for MNPs in the size range of 45-60 nm and give an improved 2-D imaging resolution of 43%, compared with an air-coil structure.
机译：磁性纳米颗粒（MNP）是在药物输送系统中用作载体的有前途的候选者。为了更精确地瞄准和诊断，不可避免地需要具有MNP实时启动和监视功能的导航系统。在本文中，我们提出了一种新颖的电磁导航系统，其线圈与软磁芯结合在一起。该系统可用于磁性粒子成像（MPI）和电磁执行器功能，具有更高的转向力和增强的监视分辨率。带线圈的软磁芯可以增加磁场梯度。但是，这也会产生谐波噪声，这使得很难通过MPI获取MNP监视信号。因此，建议使用调幅磁粉成像（AM MPI）。 AM MPI使用低振幅激励场和低频驱动场。使用该系统，被测信号对软磁芯的敏感度降低。基于新的MPI方案以及线圈与磁芯的组合，所提出的导航系统可以实现一维（1-D）MNP导航和2-D MPI。与空气线圈结构相比，对于45-60 nm尺寸范围内的MNP，所提出的导航系统可以将一维导航时间缩短约25％，并且将二维成像分辨率提高到43％。

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