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Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -

机译：分子氢的有益生物效应及其潜在机理-321篇原创文章的全面综述-

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摘要

Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. In most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. Hydrogen water is mostly given ad libitum. Hydrogen gas of less than 4% is given by inhalation. The effects have been reported in essentially all organs covering 31 disease categories that can be subdivided into 166 disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants with a predominance of oxidative stress-mediated diseases and inflammatory diseases. Specific extinctions of hydroxyl radical and peroxynitrite were initially presented, but the radical-scavenging effect of hydrogen cannot be held solely accountable for its drastic effects. We and others have shown that the effects can be mediated by modulating activities and expressions of various molecules such as Lyn, ERK, p38, JNK, ASK1, Akt, GTP-Rac1, iNOS, Nox1, NF-κB p65, IκBα, STAT3, NFATc1, c-Fos, and ghrelin. Master regulator(s) that drive these modifications, however, remain to be elucidated and are currently being extensively investigated.
机译：自2007年以来，已经研究了分子氢对多种疾病模型和人类疾病的治疗作用。从2007年至2015年6月，共发表了321篇原创文章。大多数研究在日本，中国和美国进行。大约四分之三的文章显示了对小鼠和大鼠的影响。临床试验的数量每年都在增加。在大多数疾病中，已经报道了氢气与氢气或氢气的作用，随后证实了氢气与富含氢气的盐水的作用。氢水大部分是随意提供的。吸入的氢气少于4％。据报道，这种作用基本上涵盖了涵盖31种疾病类别的所有器官，这些疾病可细分为以氧化应激介导的疾病和炎性疾病为主的植物的166种疾病模型，人类疾病，与治疗相关的病理以及病理生理状况。最初提出了羟基自由基和过氧亚硝酸盐的特定消光作用，但是氢的自由基清除作用不能仅由其剧烈作用负责。我们和其他人已经表明，可以通过调节各种分子（例如Lyn，ERK，p38，JNK，ASK1，Akt，GTP-Rac1，iNOS，Nox1，NF-κBp65，IκBα，STAT3， NFATc1，c-Fos和Ghrelin。然而，驱动这些修改的主调节器尚待阐明，目前正在广泛研究中。

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