Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model

Ira Katz; Jacqueline Murdock; Marc Palgen; Jan Pype; Georges Caillibotte

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Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model

机译：使用基于生理学的模型对惰性气体Xe和Ar的慢性给药进行药代动力学分析

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Background New gas therapies using inert gases such as xenon and argon are being studied, which would require chronically administered repeating doses. The pharmacokinetics of this type of administration has not been addressed in the literature.

机译：背景技术正在研究使用惰性气体（例如氙和氩）的新气体疗法，这将需要长期重复给药。文献中尚未涉及这种给药方式的药代动力学。

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《Medical Gas Research》 |2015年第1期|1-10|共10页
作者
Ira Katz; Jacqueline Murdock; Marc Palgen; Jan Pype; Georges Caillibotte;
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正文语种 eng
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关键词
Pharmacokinetics; Xenon; Argon; Human; Pig; Rat;

机译：药代动力学;氙;氩气人类猪;鼠;

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1. Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model [J] . Ira Katz, Jacqueline Murdock, Marc Palgen, Medical Gas Research . 2015,第1期

机译：使用基于生理学的模型对惰性气体Xe和Ar的慢性给药进行药代动力学分析
2. Predicting the Effect of Cytochrome P450 Inhibitors on Substrate Drugs: Analysis of Physiologically Based Pharmacokinetic Modeling Submissions to the US Food and Drug Administration [J] . Wagner Christian, Pan Yuzhuo, Hsu Vicky, Clinical pharmacokinetics . 2015,第Pta1期

机译：预测细胞色素P450抑制剂对底物药物的影响：分析向美国食品和药物管理局提交的基于生理学的药代动力学模型
3. Physiologically based pharmacokinetic-pharmacodynamic modeling for prediction of vonoprazan pharmacokinetics and its inhibition on gastric acid secretion following intravenous/oral administration to rats, dogs and humans [J] . Kong Wei-min, Sun Bin-bin, Wang Zhong-jian, International journal of sports medicine . 2020,第6期

机译：基于生理基础的药代动力学 - 药代动力学模型，用于预测脊柱醛药代动力学及其对大鼠，狗和人类静脉/口服施用后胃酸分泌的抑制作用
4. Physiologically Based Pharmacokinetic Modeling and Predictive Control: An integrated approach for optimal drug administration [C] . Pantelis Sopasakis, Panagiotis Patrinos, Stefania Giannikou, European symposium on computer aided process engineering;ESCAPE 21 . 2012

机译：基于生理学的药代动力学建模和预测控制：最佳药物管理的综合方法
5. Statistical Estimation of Physiologically-based Pharmacokinetic Models: Identifiability, Variation, and Uncertainty with an Illustration of Chronic Exposure to Dioxin and Dioxin-like-compounds. [D] . Thompson, Zachary. 2012

机译：基于生理学的药代动力学模型的统计估计：可识别性，变异性和不确定性，并举例说明了长期暴露于二恶英和类似二恶英的化合物。
6. Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model [O] . Ira Katz, Jacqueline Murdock, Marc Palgen, 2015

机译：使用基于生理学的模型对惰性气体Xe和Ar的慢性给药进行药代动力学分析
7. Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model [O] . Ira Katz, Jacqueline Murdock, Marc Palgen, 2015

机译：使用基于生理学的模型对惰性气体Xe和Ar的慢性给药进行药代动力学分析
8. Physiologically Based Pharmacokinetic Model for Evaluating a Simulant for Toxic Gases in Primates. [R] . Crank, W. D., Vinegar, A. 1990

机译：基于生理学的药代动力学模型评估灵长类动物毒性气体的模拟物。

Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model

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