The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis

Bruno Schneider Herrera; Leila Santana Coimbra; Agatha Ribeiro da Silva; Simone Aparecida Teixeira; Soraia Katia Pereira Costa; John Lawrence Wallace; Luis Carlos Spolidorio; Marcelo Nicolas Muscara

首页> 外文期刊>Medical Gas Research >The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis

【24h】

The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis

机译：释放H2S的萘普生衍生物ATB-346抑制结扎诱导的牙周炎大鼠的牙槽骨丢失和炎症

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Background In experimental periodontitis, non-steroidal antiinflammatory drugs (NSAIDs) effectively inhibit the resultant alveolar bone loss. However, their deleterious gastric effects, observed in both animals and humans, dramatically limit their long-term use. It has been proven that the addition of a hydrogen sulfide (H2S)-releasing moiety to classical NSAID structures results in antiinflammatory compounds with improved gastric safeness. In this way, we decided to compare the effects of naproxen with its H2S-releasing derivative ATB-346 on ligature-induced periodontitis in rats.

机译：背景技术在实验性牙周炎中，非甾体类抗炎药（NSAIDs）可有效抑制牙槽骨丢失。然而，在动物和人类中都观察到它们的有害胃作用极大地限制了它们的长期使用。业已证明，向经典的NSAID结构中添加释放硫化氢（H2S）的部分会产生具有改善的胃安全性的抗炎化合物。通过这种方式，我们决定比较萘普生及其释放H2S的衍生物ATB-346对结扎诱发的大鼠牙周炎的作用。

著录项

来源
《Medical Gas Research》 |2015年第1期|1-9|共9页
作者
Bruno Schneider Herrera; Leila Santana Coimbra; Agatha Ribeiro da Silva; Simone Aparecida Teixeira; Soraia Katia Pereira Costa; John Lawrence Wallace; Luis Carlos Spolidorio; Marcelo Nicolas Muscara;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词
Periodontitis; Bone loss; ATB-346; H2S-releasing NSAID; Inflammation;

机译：牙周炎骨丢失;ATB-346;释放H2S的NSAID;炎;

相似文献

外文文献
中文文献
专利

1. The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis [J] . Bruno S Herrera, Leila S Coimbra, Agatha R da Silva, Medical Gas Research . 2015,第1期

机译：释放H2S的萘普生衍生物ATB-346可抑制结扎诱导的牙周炎大鼠的牙槽骨丢失和炎症
2. Administration of high doses of caffeine increases alveolar bone loss in ligature-induced periodontitis in rats. [J] . Bezerra JP, da-Silva LR, de-Alvarenga-Lemos VA, Journal of Periodontology . 2008,第12期

机译：在结扎诱发的大鼠牙周炎中，高剂量咖啡因的给药会增加牙槽骨的损失。
3. The histopathological and morphometric investigation of the effects of systemically administered humic acid on alveolar bone loss in ligature-induced periodontitis in rats [J] . Calisir M., Akpinar A., Poyraz O., Journal of periodontal research . 2016,第4期

机译：全身施用腐殖酸对结扎诱导的牙周炎大鼠肺泡骨丢失影响的组织病理学和形态计量学研究
4. Alveolar bone-loss area detection in periodontitis radiographs using hybrid of intensity and texture analyzed based on FBM model [C] . Po-Whei Huang, Po-Ying Huang, Phen-Lan Lin, International Conference on Machine Learning and Cybernetics . 2014

机译：基于FBM模型的强度和质地混合分析牙周炎X线照片中的牙槽骨缺失区域
5. Effect of gender on alveolar bone loss and calculus formation in a captive baboon population. [D] . Shoff, Spencer J. 2013

机译：性别对圈养狒狒种群中牙槽骨丢失和牙结石形成的影响。
6. The H2S-releasing naproxen derivative ATB-346 inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis [O] . Bruno Schneider Herrera, Leila Santana Coimbra, Agatha Ribeiro da Silva, 2015

机译：释放H2S的萘普生衍生物ATB-346抑制结扎诱导的牙周炎大鼠的牙槽骨丢失和炎症
7. The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis [O] . Herrera, Bruno Schneider [UNESP], Coimbra, Leila Santana [UNESP], Silva, Agatha Ribeiro da, 2015

机译：释放H2S的萘普生衍生物ATB-346抑制结扎诱导的牙周炎大鼠的牙槽骨丢失和炎症

The H2S-releasing naproxen derivative, ATB-346, inhibits alveolar bone loss and inflammation in rats with ligature-induced periodontitis

摘要

著录项

相似文献

相关主题

期刊订阅