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Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia

机译：分子氢：其对双相情感障碍和精神分裂症的神经生物学作用和治疗潜力的概述

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摘要

Hydrogen gas is a bioactive molecule that has a diversity of effects, including anti-apoptotic, anti-inflammatory and anti-oxidative properties; these overlap with the process of neuroprogression in major psychiatric disorders. Specifically, both bipolar disorder and schizophrenia are associated with increased oxidative and inflammatory stress. Moreover, lithium which is commonly administered for treating bipolar disorder has effects on oxidative stress and apoptotic pathways, as do valproate and some atypical antipsychotics for treating schizophrenia. Molecular hydrogen has been studied pre-clinically in animal models for the treatment of some medical conditions including hypoxia and neurodegenerative disorders, and there are intriguing clinical findings in neurological disorders including Parkinson’s disease. Therefore, it is hypothesized that administration of hydrogen molecule may have potential as a novel therapy for bipolar disorder, schizophrenia, and other concurrent disorders characterized by oxidative, inflammatory and apoptotic dysregulation.
机译：氢气是一种生物活性分子，具有多种作用，包括抗凋亡，抗炎和抗氧化特性。这些与主要精神疾病的神经进程有关。特别地，双相情感障碍和精神分裂症均与增加的氧化应激和炎性应激有关。此外，通常用于治疗双相情感障碍的锂对氧化应激和细胞凋亡途径有影响，丙戊酸和一些非典型抗精神病药对精神分裂症也有影响。分子氢已经在动物模型中进行了临床前研究，用于治疗某些医学疾病，包括缺氧和神经退行性疾病，并且在包括帕金森氏病在内的神经系统疾病中也有有趣的临床发现。因此，假设氢分子的给药可能作为双相情感障碍，精神分裂症和其他以氧化，炎性和细胞凋亡失调为特征的并发疾病的新疗法具有潜力。

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