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Hydrogen sulfide as a vasculoprotective factor

机译：硫化氢作为血管保护因子

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摘要

Hydrogen sulfide is a novel mediator with the unique properties of a gasotransmitter and many and varied physiological effects. Included in these effects are a number of cardiovascular effects that are proving beneficial to vascular health. Specifically, H2S can elicit vasorelaxation, prevention of inflammation and leukocyte adhesion, anti-proliferative effects and anti-thrombotic effects. Additionally, H2S is a chemical reductant and nucleophile that is capable of inhibiting the production of reactive oxygen species, scavenging and neutralising reactive oxygen species and boosting the efficacy of endogenous anti-oxidant molecules. These result in resistance to oxidative stress, protection of vascular endothelial function and maintenance of blood flow and organ perfusion. H2S has been shown to be protective in hypertension, atherosclerosis and under conditions of vascular oxidative stress, and deficiency of endogenous H2S production is linked to cardiovascular disease states. Taken together, these effects suggest that H2S has a physiological role as a vasculoprotective factor and that exogenous H2S donors may be useful therapeutic agents. This review article will discuss the vascular effects and anti-oxidant properties of H2S as well as examine the protective role of H2S in some important vascular disease states.
机译：硫化氢是一种新型的介体，具有气体发送器的独特性能以及多种生理效应。这些作用包括许多对心血管健康有益的心血管作用。特别地，H 2 S可以引起血管舒张，预防炎症和白细胞粘附，抗增殖作用和抗血栓形成作用。此外，H2S是一种化学还原剂和亲核试剂，能够抑制活性氧的产生，清除和中和活性氧并提高内源性抗氧化剂分子的功效。这些导致对氧化应激的抵抗，保护血管内皮功能以及维持血流和器官灌注。已显示H2S在高血压，动脉粥样硬化和血管氧化应激条件下具有保护作用，内源性H2S产生的缺乏与心血管疾病状态有关。综上所述，这些作用表明H2S具有作为血管保护因子的生理作用，并且外源H2S供体可能是有用的治疗剂。这篇综述文章将讨论H2S的血管作用和抗氧化特性，并探讨H2S在某些重要的血管疾病状态中的保护作用。

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