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首页> 外文期刊>Microchimica Acta >Redox-amplified biosensors based on selective modification of nanopore electrode structures with enzymes entrapped within electrodeposition paints
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Redox-amplified biosensors based on selective modification of nanopore electrode structures with enzymes entrapped within electrodeposition paints

机译：基于选择性修饰纳米孔电极结构的氧化还原放大生物传感器，其中的酶被电沉积涂料中捕获的酶

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摘要

An electrode structure consisting of two separately addressable electrodes with 200 nm inter-electrode spacing in a layered nanoporous electrode/insulator/electrode configuration was used as transducer for redox-amplified biosensors. Nanopores were selectively modified with two different enzymes, namely glucose oxidase and alkaline phosphatase by means of electrochemically induced precipitation of electrodeposition paints. Both commercially available and specifically synthesized redox-active electrodeposition paints were used. Selectivity of modification was proven by electrochemical methods and atomic force microscopy. The principle feasibility to amplify the measured current in a model sensor based on alkaline phosphatase could be demonstrated. Signal amplification by a factor of two with respect to the non-amplified response was achieved.
机译：电极结构由两个可寻址电极组成，电极间的电极间距为200纳米，呈层状纳米孔电极/绝缘体/电极结构，被用作氧化还原扩增生物传感器的传感器。通过电化学诱导的电沉积涂料沉淀，用两种不同的酶，即葡萄糖氧化酶和碱性磷酸酶，选择性地修饰了纳米孔。使用市售的和专门合成的氧化还原活性电沉积涂料。通过电化学方法和原子力显微镜证实了修饰的选择性。可以证明在基于碱性磷酸酶的模型传感器中放大测量电流的原理可行性。相对于未放大的响应，信号放大了两倍。

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