...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Microelectronic Engineering >Development of silicon microneedle arrays with spontaneously generated micro-cavity ring for transdermal drug delivery
【24h】

Development of silicon microneedle arrays with spontaneously generated micro-cavity ring for transdermal drug delivery

机译：具有自发产生的微腔环的硅微针阵列的开发，用于透皮给药

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Transdermal drug delivery techniques based on microneedle arrays can painlessly administer controlled amount of drugs through penetration of the epidermis. Solid microneedles arrays can be employed in this process after coating the tip with the liquid agent before insertion. In this work, we report a low cost technique for the formation of pyramidal microneedle arrays based on crystalline silicon. A combination of crystallographic etching, thermal oxidation and subsequent HNA treatment was employed. Optimization of the process parameters led to the generation of pyramidal microneedle arrays where the tip diameter can be reduced without loss of overall structural robustness. Micro-cavities with size 4-10 gm in diameter can be reproducibly generated in a ring surrounding the tip, while maintaining an otherwise smooth microneedle facet wall. Optical fluorescence imaging indicates that fluids can be exclusively trapped in these microcavities, with implications in transdermal drug delivery.
机译：基于微针阵列的透皮给药技术可以通过表皮的渗透而无痛地给药控制量的药物。固体微针阵列可在插入之前用液体试剂涂覆针尖后用于此过程。在这项工作中，我们报告了一种低成本的技术，用于基于晶体硅的金字塔形微针阵列的形成。结合了晶体学蚀刻，热氧化和随后的HNA处理。工艺参数的优化导致产生了金字塔形微针阵列，在不损失整体结构坚固性的情况下，可以减小尖端直径。直径4-10 gm的微腔可以在围绕尖端的环中重现，同时保持原本光滑的微针小平面壁。光学荧光成像表明，可以将流体专门捕获在这些微腔中，这可能会影响透皮给药。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号