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首页> 外文期刊>Microelectronic Engineering >Fabrication of polymer fiber scaffolds by centrifugal spinning for cell culture studies
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Fabrication of polymer fiber scaffolds by centrifugal spinning for cell culture studies

机译：通过离心纺丝制备聚合物纤维支架以进行细胞培养研究

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摘要

We demonstrate a mass production amenable technology for the fabrication of polymer fibers that can be used as 3D scaffolds for cell culture and tissue engineering. As the first attempt, we used centrifugal melt spinning technique to fabricate fiber matrix of poly-lactic-co-glycolic acid (PLGA) which is a well-known biodegradable co-polymer. We then developed a solvent assisted centrifugal spinning technique to produce fiber matrix of polystyrene (PS) which has a relative high glass transition temperature comparing to that of PLGA. Both melt spinning and solvent assisted spinning techniques were studied with two types of commercial cotton-candy machines. Finally, the fabricated fibers were used as scaffolds for cell culture, showing application potentials for large volume cell proliferation.
机译：我们展示了可用于制造聚合物纤维的批量生产技术，该技术可用作细胞培养和组织工程的3D支架。作为首次尝试，我们使用离心熔融纺丝技术制造了聚乳酸-乙醇酸（PLGA）纤维基质，该纤维是众所周知的可生物降解的共聚物。然后，我们开发了一种溶剂辅助离心纺丝技术来生产聚苯乙烯（PS）纤维基质，与PLGA相比，该纤维基质的玻璃化转变温度较高。使用两种类型的商用棉花糖机研究了熔纺和溶剂辅助纺丝技术。最后，将制成的纤维用作细胞培养的支架，显示出大量细胞增殖的应用潜力。

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  • 来源
    《Microelectronic Engineering》 |2011年第8期|p.1718-1721|共4页
  • 作者

    Li Wang; Jian Shi; Li Liu; Emilie Secret; Yong Chen;

  • 作者单位

    Institute for Integrated Cell-Material Sciences. Kyoto University, 606-8507 Kyoto. Japan Ecole Normale Superieure. CNRS-ENS-UPMC UMR 8640.24 rue Lhomond, 75231 Paris. France;

    Institute for Integrated Cell-Material Sciences. Kyoto University, 606-8507 Kyoto. Japan Ecole Normale Superieure. CNRS-ENS-UPMC UMR 8640.24 rue Lhomond, 75231 Paris. France;

    Institute for Integrated Cell-Material Sciences. Kyoto University, 606-8507 Kyoto. Japan;

    Ecole Normale Superieure. CNRS-ENS-UPMC UMR 8640.24 rue Lhomond, 75231 Paris. France;

    Institute for Integrated Cell-Material Sciences. Kyoto University, 606-8507 Kyoto. Japan Ecole Normale Superieure. CNRS-ENS-UPMC UMR 8640.24 rue Lhomond, 75231 Paris. France Institute for Integrated Cell-Material Sciences, Kyoto University, 606-8507 Kyoto. Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    polymer fibers; scaffolds; cell culture; tissue engineering;

    机译：聚合物纤维;支架;细胞培养;组织工程;

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