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首页> 外文期刊>Molecular & Cellular Toxicology >Genomic expression responses toward bisphenol-A toxicity in Daphnia magna in terms of reproductive activity
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Genomic expression responses toward bisphenol-A toxicity in Daphnia magna in terms of reproductive activity

机译：就生殖活性而言，水蚤对双酚A毒性的基因组表达反应

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Bisphenol-A(BPA) classified as an endocrine disruptor that can interfere endocrine system, leading to adverse developmental, reproductive, neurological, and immunological effects in both humans and wildlife. To study the reproductive and geno-toxicological effects of BPA in aquatic ecosystem, we employed Daphnia magna (D. magna) as a test animal model. D. magna in one of the most widely used water species employed in ecotoxicology testing all over the world. As a result, the reproductive activity based on the number of offspring production is significantly reduced toward 21 day exposure to 10 mg/L of BPA, compared with control. Gene expression profiles in response to BPA exposure using DNA microarray analysis was subsequently carried out. Our data showed that expression levels of numerous putative genes with nucleotide sequences homology to animal models including cuticular protein, vitellogenin, protease, ribosomal protein family were altered. These genes which are critically reported in other animal systems could be considered as novel biomarkers in response to BPA exposure.
机译：双酚A（BPA）被归类为一种内分泌干扰物，可以干扰内分泌系统，从而对人类和野生生物造成不利的发育，生殖，神经和免疫学影响。为了研究双酚A在水生生态系统中的生殖和遗传毒理学作用，我们以水蚤（Daphnia magna）为试验动物模型。 D. magna是全世界生态毒理学测试中使用最广泛的水物种之一。结果，与对照相比，在暴露于10 mg / L BPA的第21天时，基于后代生产数量的生殖活性显着降低。随后利用DNA微阵列分析进行了响应于BPA暴露的基因表达谱。我们的数据表明，与动物模型（包括表皮蛋白，卵黄蛋白原，蛋白酶，核糖体蛋白家族）具有核苷酸序列同源性的许多推定基因的表达水平均发生了改变。这些在其他动物系统中关键报道的基因可以被认为是对BPA暴露的新生物标记。

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