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首页> 外文期刊>NanoBioscience, IEEE Transactions on >Tumor-Targeted Quantum Dots Can Help Surgeons Find Tumor Boundaries
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Tumor-Targeted Quantum Dots Can Help Surgeons Find Tumor Boundaries

机译：靶向肿瘤的量子点可以帮助外科医生找到肿瘤边界

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Despite surgical advances and recent progress in adjuvant therapies, the prognosis for patients with malignant brain tumors such as glioblastoma multiforme has remained poor, and the neurological deterioration suffered by most patients as a consequence of tumor progression is dramatic and severe. In addition, malignant brain tumors have > 95% recurrence close to the primary site of initial resection. Unfortunately, standard imaging techniques do not permit the intraoperative identification of individual or small clusters of residual tumor cells, precluding their selective removal while sparing the surrounding normal brain tissue. In this report, we show that quantum dots (QDs) coupled to epidermal growth factor (EGF) or anti-EGF receptor (EGFR, Her1) specifically and sensitively label glial tumor cells in cell culture, glioma mouse models, and human brain-tumor biopsies. A clear demarcation between brain and tumor tissue at the macroscopic as well as the cellular level is provided by the fluorescence emission of the QDs.
机译：尽管在外科手术方面取得了进展并且辅助治疗方面有了新的进展，但是恶性脑肿瘤例如多形性胶质母细胞瘤的患者的预后仍然很差，并且大多数患者由于肿瘤进展而遭受的神经系统恶化是剧烈而严重的。此外，恶性脑肿瘤在初次切除的主要部位附近复发率> 95％。不幸的是，标准的成像技术不允许在术中鉴定单个或小的残留肿瘤细胞簇，从而排除了它们在保留周围正常脑组织的同时选择性去除的可能性。在本报告中，我们显示了量子点（QD）与表皮生长因子（EGF）或抗EGF受体（EGFR，Her1）偶联，可在细胞培养，神经胶质瘤小鼠模型和人脑肿瘤中特异性和敏感地标记神经胶质瘤细胞活检。量子点的荧光发射在宏观和细胞水平上在大脑和肿瘤组织之间提供了清晰的界限。

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