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首页> 外文期刊>NanoBioscience, IEEE Transactions on >Magnetically Responsive Nanoparticles for Drug Delivery Applications Using Low Magnetic Field Strengths
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Magnetically Responsive Nanoparticles for Drug Delivery Applications Using Low Magnetic Field Strengths

机译:使用低磁场强度的药物递送应用中的磁响应纳米颗粒

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The purpose of this study is to investigate the potential of magnetic nanoparticles for enhancing drug delivery using a low oscillating magnetic field (OMF) strength. We investigated the ability of magnetic nanoparticles to cause disruption of a viscous biopolymer barrier to drug delivery and the potential to induce triggered release of drug conjugated to the surfaces of these particles. Various magnetic nanoparticles were screened for thermal response under a 295-kHz OMF with an amplitude of 3.1 kA/m. Based on thermal activity of particles screened, we selected the nanoparticles that displayed desired characteristics for evaluation in a simplified model of an extracellular barrier to drug delivery, using lambda DNA/HindIII. Results indicate that nanoparticles could be used to induce DNA breakage to enhance local diffusion of drugs, despite low temperatures of heating. Additional studies showed increased diffusion of quantum dots in this model by single-particle tracking methods. Bimane was conjugated to the surface of magnetic nanoparticles. Fluorescence and transmission electron microscope images of the conjugated nanoparticles indicated little change in the overall appearance of the nanoparticles. A release study showed greater drug release using OMF, while maintaining low bulk heating of the samples (T=30degC). This study indicates that lower magnetic field strengths may be successfully utilized for drug delivery applications as a method for drug delivery transport enhancement and drug release switches.
机译:这项研究的目的是研究使用低振荡磁场(OMF)强度的磁性纳米粒子增强药物递送的潜力。我们研究了磁性纳米颗粒引起粘性生物聚合物屏障对药物递送的破坏的能力,以及诱导与这些颗粒表面偶联的药物的触发释放的潜力。在振幅为3.1 kA / m的295 kHz OMF下筛选各种磁性纳米粒子的热响应。基于所筛选颗粒的热活性,我们选择了显示出所需特性的纳米颗粒,以使用lambda DNA / HindIII在简化的细胞外药物传递屏障模型中进行评估。结果表明,尽管加热温度低,纳米颗粒仍可用于诱导DNA断裂,以增强药物的局部扩散。其他研究表明,通过单粒子跟踪方法,该模型中量子点的扩散增加。 Bimane共轭到磁性纳米粒子的表面。共轭纳米颗粒的荧光和透射电子显微镜图像表明纳米颗粒的整体外观几乎没有变化。释放研究表明,使用OMF可以释放更多的药物,同时保持较低的样品整体加热(T = 30degC)。这项研究表明,较低的磁场强度可以成功地用于药物输送应用,作为增强药物输送传输和释放药物的方法。

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