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Effect of Pore Size on the Calculated Pressure at Biological Cells Pore Wall

机译:孔径对生物细胞孔壁计算压力的影响

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A transient nonlinear finite-element program has been used to calculate the electric field distribution as a function of time for a spherical cell with a pore in a conducting medium during application of a subnanosecond rise time “step” wave, including the effects of dipolar saturation in the water-based cytoplasm and cell medium. The time-dependent pressure on the pore wall has been computed as a function of time as the system polarizes from the change of the energy in the electric field to the left (inside the pore) and to the right (inside the membrane) of the pore wall. The computations suggest that dipolar saturation, while significant, has little effect on the time-dependent electric field distribution but a substantial effect on the field-induced pore wall pressure. Also, the effect of pore size on both the computed electric field and field-induced pressure was studied. As the pore size increases, a collapse in both the electric field and field-induced pressure has been noticed. This suggests that as the pore size increases, the driving force for further opening the pore is not electrical.
机译:瞬态非线性有限元程序已被用于计算在亚纳秒上升时间“阶梯”波的作用下,在导电介质中带有孔的球形单元的时间随时间变化的电场分布,包括偶极饱和度的影响在水性细胞质和细胞培养基中。当系统从电场的能量向极化的左侧(孔隙内部)和右侧(膜内部)的变化极化时,孔隙壁上随时间变化的压力已作为时间的函数进行了计算。孔壁。计算表明,偶极饱和虽然很明显,但对随时间变化的电场分布影响很小,但对场感应孔壁压力影响很大。此外,研究了孔径对计算电场和场致压力的影响。随着孔径的增加,已经注意到电场和场致压力都崩溃。这表明,随着孔径的增加,进一步打开孔的驱动力不是电的。

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