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首页> 外文期刊>IEEE transactions on nanobioscience >Synthesizing Biofunctionalized Nanoparticles to Image Cell Signaling Pathways
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Synthesizing Biofunctionalized Nanoparticles to Image Cell Signaling Pathways

机译:合成生物功能化的纳米粒子以成像细胞信号通路。

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摘要

This minireview outlines the synthetic efforts, from our research group, to produce nanomaterials for use as imaging agents to study cell signaling pathways. An overview of our approach to the synthesis and biofunctionalization of metal, semiconductor, and ceramic nanomaterials is presented. The probes investigated include coinage metals, Cd-based, Gedeg, naturally occurring fluorescent (NOF) minerals, and Ln-based nanoparticles which were synthesized from novel metal alkoxide, amide, and alkyl precursors. We illustrate the applications of some of these materials as imaging probes to detect signaling pathway components and cellular responses to signals (apoptosis and degranulation) in inflammatory and cancer cells
机译:这份小型综述概述了我们研究小组为生产用作成像剂以研究细胞信号传导途径的纳米材料而进行的合成工作。概述了我们对金属,半导体和陶瓷纳米材料进行合成和生物功能化的方法。研究的探针包括造币金属,Cd基,Gedeg,天然存在的荧光(NOF)矿物和Ln基纳米颗粒,它们是由新型金属醇盐,酰胺和烷基前体合成的。我们举例说明了其中一些材料作为成像探针在炎症细胞和癌细胞中检测信号传导途径成分和细胞对信号(凋亡和脱粒)的反应的应用。

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