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首页> 外文期刊>Nanobiotechnology, IET >Zinc oxide nanoparticles augment CD4, CD8, and GLUT-4 expression and restrict inflammation response in streptozotocin-induced diabetic rats
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Zinc oxide nanoparticles augment CD4, CD8, and GLUT-4 expression and restrict inflammation response in streptozotocin-induced diabetic rats

机译：氧化锌纳米颗粒增强CD4，CD8和凝乳 - 4表达，并限制链脲佐菌素诱导的糖尿病大鼠中的炎症反应

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摘要

This study evaluated the biochemical, molecular, and histopathological mechanisms involved in the hypoglycaemic effect of zinc oxide nanoparticles (ZnONPs) in experimental diabetic rats. ZnONPs were prepared by the sol-gel method and characterised by scanning and transmission electron microscopy (SEM and TEM). To explore the possible hypoglycaemic and antioxidant effect of ZnONPs, rats were grouped as follows: control group, ZnONPs treated group, diabetic group, and diabetic + ZnONPs group. Upon treatment with ZnONPs, a significant alteration in the activities of superoxide dismutase, glutathione peroxidase, and the levels of insulin, haemoglobin A1c, and the expression of cluster of differentiation 4+ (CD4+), CD8+ T cells, glucose transporter type-4 (GLUT-4), tumour necrosis factor, and interleukin-6 when compared to diabetic and their control rats. ZnONPs administration to the diabetic group showed eminent blood glucose control and restoration of the biochemical profile. This raises their active role in controlling pancreas functions to improve glycaemic status as well as the inflammatory responses. Histopathological investigations showed the non-toxic and therapeutic effect of ZnONPs on the pancreas. TEM of pancreatic tissues displayed restoration of islets of Langerhans and increased insulin-secreting granules. This shows the therapeutic application of ZnONPs as a safe anti-diabetic agent and to have a potential for the control of diabetes.
机译：该研究评估了参与实验糖尿病大鼠氧化锌纳米颗粒（ZnOnps）的低血糖作用的生物化学，分子和组织病理学机制。通过溶胶 - 凝胶法制备ZnOnps并通过扫描和透射电子显微镜（SEM和TEM）来表征。为了探讨Znonps可能的低血基和抗氧化效果，大鼠分组如下：对照组，ZnOnps组，糖尿病组和糖尿病+ ZnOnps组。用ZnOnps治疗后，超氧化物歧化酶，谷胱甘肽过氧化物酶和胰岛素，血红蛋白A1C水平的显着改变，分化4 +（CD4 +），CD8 + T细胞，葡萄糖转运蛋白类型-4（与糖尿病及其对照大鼠相比，凝乳4），肿瘤坏死因子和白细胞介素-6。 ZnOnps施用给糖尿病组，显示出致血糖控制和生物化学型材的恢复。这提高了它们在控制胰腺功能中的活跃作用，以提高血糖状态以及炎症反应。组织病理学调查显示Znonps对胰腺的无毒和治疗效果。胰腺组织的TEM显示兰犬胰岛胰岛的恢复，增加胰岛素分泌颗粒。这表明Znonps作为安全抗糖尿病剂的治疗施用，并且具有对糖尿病的控制潜力。

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