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首页> 外文期刊>Nanobiotechnology, IET >Assessment of acaricidal activity of nanoscale ZnO encapsulated piperine formulation against Rhipicephalus microplus
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Assessment of acaricidal activity of nanoscale ZnO encapsulated piperine formulation against Rhipicephalus microplus

机译：评估纳米氧化氮包封哌啶制剂的杀螨活性对雷地氏菌微米

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摘要

This study aims to synthesise and evaluate the acaricidal activity of nanoscale zinc oxide piperine formulation (NZPF) against Rhipicephalus microplus ticks. NZPF was prepared by using zinc oxide nanoparticles (ZnONPs) and piperine by employing encapsulation technique; characterised by UV spectroscopy, Fourier transformed infrared analysis, X-ray diffraction, dynamic light scattering, zetapotential and scanning electron microscopy. Acaricidal activity of the NZPF on R. microplus was evaluated using larval packet test (LPT) and adult immersion test (AIT). LPT against R. microplus larvae showed an LC50 at 1 mg/l for NZPF followed by 2 and 3 mg/l for ZnONPs and piperine, respectively. AIT against R. microplus showed an LC50 at concentration of 3 mg/l for NZPF followed by 6 mg/l for ZnONPs and 7 mg/l for piperine. In both LPT and AIT, LC50 values of ZnONPs and NZPF were significantly lower compared to deltamethrin. NZPF showed significant ovulation inhibitory activity with lower IC50 and IC99 values compared to ZnONPs and piperine. NZPF has been proved to be the better alternative to routine chemical acaricides for control of tick infestation of cattle in the wake of acaricidal resistance, but safety issues need to be addressed before clinical application.
机译：本研究旨在综合和评估纳米级氧化锌哌啶制剂（NZPF）的杀螨活性对抗Rapicephalus Microplus蜱虫。通过采用封装技术，通过使用氧化锌纳米颗粒（ZnOnps）和哌啶制备NZPF;特征在于UV光谱，傅里叶变换红外分析，X射线衍射，动态光散射，ZetApotential和扫描电子显微镜。使用幼虫分组试验（LPT）和成人浸渍试验（AIT）评估NZPF对r.PR.Micloplus的Agaricidal活性。 LPT对抗R. Microplus幼虫显示为1mg / L的LC50，对于NZPF，分别为ZnOnps和哌啶的2和3mg / L. AIT对抗R.微孔显示LC50，浓度为NZPF为3mg / L，其次为ZnOnps和哌啶的7mg / L.与溴氰菊酯相比，在LPT和AIT中，ZnOnps和NZPF的LC50值显着降低。与ZnOnps和哌啶相比，NZPF显示出具有较低IC50和IC99值的显着排卵抑制活性。 NZPF已被证明是常规替代常规的常规化学杀螨剂，用于控制杀螨剂的蜱虫蜱灭绝，但在临床应用之前需要解决安全问题。

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