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Biofabrication of broad range antibacterial and antibiofilm silver nanoparticles

机译：广泛的抗菌和生物膜银纳米颗粒的生物制造

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Silver nanoparticles (AgNPs) were biosynthesized via a green route using ten different plants extracts (GNP1- Caryota urens, GNP2-Pongamia glabra, GNP3- Hamelia patens, GNP4-Thevetia peruviana, GNP5-Calendula officinalis, GNP6-Tectona grandis, GNP7-Ficus petiolaris, GNP8- Ficus busking, GNP9- Juniper communis, GNP10-Bauhinia purpurea). AgNPs were tested against drug resistant microbes and their biofilms. These nanoparticles (NPs) were characterised using UV-vis spectroscopy, transmission electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction and Image J software. Most of the AgNPs were distributed over a range of 1 of 60 nm size. The results indicated that AgNPs were antibacterial in nature without differentiating between resistant or susceptible strains. Moreover, the effect was more prominent on Gram negative bacteria then Gram positive bacteria and fungus. AgNPs inhibited various classes of microbes with different concentration. It was also evident from the results that the origin or nature of extract did not affect the activity of the NPs. Protein and carbohydrate leakage assays confirmed that the cells lysis is one of the main mechanisms for the killing of microbes by green AgNPs. This study suggests that the action of AgNPs on microbial cells resulted into cell lysis and DNA damage. Excellent microbial biofilm inhibition was also seen by these green AgNPs. AgNPs have proved their candidature as a potential antibacterial and antibiofilm agent against MDR microbes.
机译：使用十种不同的植物提取物（GNP1- Caryota urens，GNP2-Pongamia glabra，GNP3- Hamelia patens，GNP4-Thevetia peruviana，GNP5-Calendula officinalis，GNP6-Tectona grandis，GNP7-Ficus）通过绿色途径生物合成银纳米颗粒（AgNPs）。矮牵牛，GNP8-榕树，GNP9-杜松，GNP10-紫荆花）。对AgNPs进行了抗药性微生物及其生物膜的测试。使用紫外可见光谱，透射电子显微镜，傅立叶变换红外光谱，X射线衍射和Image J软件对这些纳米颗粒（NP）进行表征。大多数AgNP分布在60 nm大小的1范围内。结果表明，AgNPs本质上是抗菌的，没有区分抗性或易感菌株。此外，对革兰氏阴性细菌的效果比对革兰氏阳性细菌和真菌的效果更显着。 AgNPs抑制浓度不同的各种微生物。从结果还可以看出，提取物的来源或性质不影响NP的活性。蛋白质和碳水化合物泄漏测定证实细胞裂解是绿色AgNP杀死微生物的主要机制之一。这项研究表明，AgNPs对微生物细胞的作用导致细胞裂解和DNA损伤。这些绿色的AgNPs还具有出色的微生物生物膜抑制作用。 AgNPs已被证明是潜在的抗MDR微生物的抗菌和抗生物膜剂。

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