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首页> 外文期刊>Nanobiotechnology, IET >Uptake and clearance analysis of Technetium99m labelled iron oxide nanoparticles in a rabbit brain
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Uptake and clearance analysis of Technetium99m labelled iron oxide nanoparticles in a rabbit brain

机译：net 99m 标记的氧化铁纳米颗粒在兔脑中的摄取和清除分析

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Nanoparticles as solid colloidal particles are extensively studied and used as anticancer drug delivery agents because of their physical properties. This current research aims to prepare water base suspension of uncoated iron oxide nanoparticles and their biodistribution study to different organs, especially the brain, by using a single photon emission computed tomography gamma camera. The water-based suspension of iron oxide nanoparticles was synthesised by a reformed version of the co-precipitation method and labelled with Tc for intravenous injection. The nanoparticles were injected without surface modification. X-ray diffraction (XRD), energy dispersive spectrometry (EDS) and transmission electron microscope (TEM) techniques were used for characterisation. Peaks of XRD and EDS indicate that the particles are magnetite and exist in aqueous suspension. The average diameter of iron oxide nanoparticles without any surface coating determined by TEM is 10 nm. These particles are capable of evading the reticuloendothelial system and can cross the blood-brain barrier in the rabbit. The labelling efficiency of iron oxide nanoparticles labelled with Tc is 85%, which is good for the biodistribution study. The sufficient amount of iron oxide nanoparticles concentration in the brain as compared with the surrounding soft tissues and their long blood retention time indicates that the water-based suspension of iron oxide nanoparticles may be an option for drug delivery into the brain.
机译：作为固体胶体颗粒的纳米颗粒由于其物理性质而被广泛研究并用作抗癌药物递送剂。这项当前的研究旨在通过使用单光子发射计算机断层摄影伽马相机来制备未涂覆的氧化铁纳米粒子的水基悬浮液，并将其生物分布研究到不同器官，特别是大脑。氧化铁纳米粒子的水基悬浮液是通过共沉淀方法的改良版合成的，并用Tc标记用于静脉注射。纳米颗粒无需表面改性即可注入。 X射线衍射（XRD），能量色散光谱（EDS）和透射电子显微镜（TEM）技术用于表征。 XRD和EDS的峰表明该颗粒是磁铁矿并且存在于水悬浮液中。通过TEM确定的没有任何表面涂层的氧化铁纳米颗粒的平均直径为10nm。这些颗粒能够逃避网状内皮系统，并且可以穿越兔的血脑屏障。 Tc标记的氧化铁纳米颗粒的标记效率为85％，对生物分布研究有好处。与周围的软组织相比，大脑中足够的氧化铁纳米颗粒浓度及其较长的血液滞留时间表明，氧化铁纳米颗粒的水基悬浮液可能是药物递送至大脑的一种选择。

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