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Use of cell morphology as early bioindicator for viral infection

机译:细胞形态学作为病毒感染的早期生物指标的应用

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This study reports a correlation between cellular morphology and the ability of adapting to vesicular stomatitis virus infection. A time-lapse approach was employed to track the individual difference between homologous cells in adapting to viral infection. The authors single-cell analysis indicates that upon viral infection, mature cells that are in spindle shape are less likely to be infected after 24 h infection. On the other hand, cells undergoing proliferation, which are in rounder shape, tend to adopt a much higher viral infection within the same amount of time. This fact suggests that cellular morphology may be an early bioindicator for viral infection. The findings in this study could potentially be applied to other viral infection models.
机译:这项研究报告了细胞形态与适应水疱性口炎病毒感染的能力之间的相关性。采用延时方法来追踪同源细胞之间在适应病毒感染中的个体差异。作者的单细胞分析表明,病毒感染后,呈纺锤状的成熟细胞在感染24小时后就不太可能被感染。另一方面,呈圆形的经历增殖的细胞倾向于在相同的时间内接受更高的病毒感染。这个事实表明细胞形态可能是病毒感染的早期生物指标。这项研究中的发现可能会应用于其他病毒感染模型。

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