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The logic of single-cell projections from visual cortex

机译：视觉皮层中单细胞投影的逻辑

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摘要

Neocortical areas communicate through extensive axonal projections, but the logic of information transfer remains poorly understood, because the projections of individual neurons have not been systematically characterized. It is not known whether individual neurons send projections only to single cortical areas or distribute signals across multiple targets. Here we determine the projection patterns of 591 individual neurons in the mouse primary visual cortex using whole-brain fluorescence-based axonal tracing and high-throughput DNA sequencing of genetically barcoded neurons (MAPseq). Projections were highly diverse and divergent, collectively targeting at least 18 cortical and subcortical areas. Most neurons targeted multiple cortical areas, often in non-random combinations, suggesting that sub-classes of intracortical projection neurons exist. Our results indicate that the dominant mode of intracortical information transfer is not based on 'one neuron-one target area' mapping. Instead, signals carried by individual cortical neurons are shared across subsets of target areas, and thus concurrently contribute to multiple functional pathways.
机译：新皮质区域通过广泛的轴突投影进行通信，但是信息传递的逻辑仍然知之甚少，因为单个神经元的投影尚未得到系统地表征。尚不清楚单个神经元是仅将投影发送到单个皮质区域还是将信号分布在多个目标上。在这里，我们使用基于全脑荧光的轴突示踪和遗传条形​​码神经元（MAPseq）的高通量DNA测序，确定了小鼠初级视觉皮层中591个单个神经元的投影模式。投影高度多样化且差异很大，共同针对至少18个皮质和皮质下区域。大多数神经元通常以非随机组合靶向多个皮质区域，这表明存在皮质内投射神经元的亚类。我们的结果表明，皮质内信息转移的主导模式不是基于“一个神经元-一个目标区域”的映射。相反，由单个皮质神经元携带的信号在目标区域的子集之间共享，因此同时有助于多种功能途径。

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  • 来源
    《Nature》 |2018年第7699期|51-56|共6页
  • 作者

    Han Yunyun; Kebschull Justus M.; Campbell Robert A. A.; Cowan Devon; Imhof Fabia; Zador Anthony M.; Mrsic-Flogel Thomas D.;

  • 作者单位

    Huazhong Univ Sci & Technol, Sch Basic Med, Dept Neurobiol, Wuhan, Hubei, Peoples R China;

    Watson Sch Biol Sci, Cold Spring Harbor, NY USA;

    Univ Basel, Biozentrum, CH-4056 Basel, Switzerland;

    Univ Basel, Biozentrum, CH-4056 Basel, Switzerland;

    Univ Basel, Biozentrum, CH-4056 Basel, Switzerland;

    Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA;

    Univ Basel, Biozentrum, CH-4056 Basel, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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