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首页> 外文期刊>Neuron >Receptive-field modification in rat visual cortex induced by paired visual stimulation and single-cell spiking.
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Receptive-field modification in rat visual cortex induced by paired visual stimulation and single-cell spiking.

机译：配对视觉刺激和单细胞尖峰诱导的大鼠视觉皮层的感受野修饰。

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摘要

Experience-dependent plasticity of visual cortical receptive fields (RFs) involves synaptic modifications in the underlying neural circuits, but the site and mechanism of these modifications remain to be elucidated. Using in vivo whole-cell recordings, we show that pairing visual stimulation at a given retinal location with spiking of a single neuron in developing rat visual cortex induces rapid RF modifications. The time course of the response to the visual stimulus at the paired RF location is altered, with an enhancement of the response preceding the spike time and a reduction following the spike. Such bidirectional modification is consistent with spike timing-dependent plasticity. Response modification also occurs at nearby locations, the direction and magnitude of which are correlated with the change at the paired location. In addition, changes at unpaired locations show a negative correlation with the initial strength of the response, which may facilitate rapid modification of the spatial RF profile.
机译：视皮层感受野（RF）的经验依赖性可塑性涉及潜在的神经回路中的突触修饰，但这些修饰的部位和机制仍有待阐明。使用体内全细胞记录，我们显示在给定的视网膜位置视觉刺激与发展中的大鼠视觉皮层中单个神经元的尖峰配对可诱导快速的RF修饰。配对RF位置对视觉刺激的响应的时程发生了变化，尖峰时间之前的响应增强，而尖峰之后的响应减小。这种双向修改与尖峰时间相关的可塑性一致。响应修改也发生在附近的位置，其方向和大小与配对位置的变化相关。此外，未配对位置的变化与响应的初始强度呈负相关，这可能有助于快速修改空间RF轮廓。

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