• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >A stromal cell population that inhibits adipogenesis in mammalian fat depots
【24h】

A stromal cell population that inhibits adipogenesis in mammalian fat depots

机译：抑制哺乳动物脂肪库中脂肪形成的基质细胞群

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Adipocyte development and differentiation have an important role in the aetiology of obesity and its co-morbidities(1,2). Although multiple studies have investigated the adipogenic stem and precursor cells that give rise to mature adipocytes(3-14), our understanding of their in vivo origin and properties is incomplete(2,15,16). This is partially due to the highly heterogeneous and unstructured nature of adipose tissue depots(17), which has proven difficult to molecularly dissect using classical approaches such as fluorescence-activated cell sorting and Cre-lox lines based on candidate marker genes(16,18). Here, using the resolving power of single-cell transcriptomics(19) in a mouse model, we reveal distinct subpopulations of adipose stem and precursor cells in the stromal vascular fraction of subcutaneous adipose tissue. We identify one of these subpopulations as CD142(+) adipogenesis- regulatory cells, which can suppress adipocyte formation in vivo and in vitro in a paracrine manner. We show that adipogenesis-regulatory cells are refractory to adipogenesis and that they are functionally conserved in humans. Our findings point to a potentially critical role for adipogenesis-regulatory cells in modulating adipose tissue plasticity, which is linked to metabolic control, differential insulin sensitivity and type 2 diabetes.
机译：脂肪细胞的发育和分化在肥胖及其合并症的病因学中具有重要作用（1,2）。尽管多项研究已经研究了可产生成熟脂肪细胞的成脂干细胞和前体细胞（3-14），但我们对它们的体内起源和特性的了解还不完整（2,15,16）。这部分是由于脂肪组织贮库的高度异质性和非结构化性质（17），事实证明，使用经典方法（例如基于候选标记基因的荧光激活细胞分选和Cre-lox系）很难进行分子解剖（16,18） ）。在这里，使用单细胞转录组学（19）在小鼠模型中的分辨能力，我们揭示了皮下脂肪组织基质血管部分中脂肪干细胞和前体细胞的不同亚群。我们确定这些亚群之一为CD142（+）脂肪生成调节细胞，它可以在体内和体外以旁分泌方式抑制脂肪细胞的形成。我们表明，脂肪形成调节细胞难于脂肪形成，并且它们在人类中功能保守。我们的发现指出，脂肪形成调节细胞在调节脂肪组织可塑性方面具有潜在的关键作用，这与代谢控制，胰岛素敏感性差异和2型糖尿病有关。

著录项

  • 来源
    《Nature》 |2018年第7712期|103-108|共6页
  • 作者

    Schwalie Petra C.; Dong Hua; Zachara Magda; Russeil Julie; Alpern Daniel; Akchiche Nassila; Caprara Christian; Sun Wenfei; Schlaudraff Kai-Uwe; Soldati Gianni; Wolfrum Christian; Deplancke Bart;

  • 作者单位

    Ecole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, Lab Syst Biol & Genet, Lausanne, Switzerland;

    Eidgenoss Tech Hsch Zurich, Inst Food Nutr & Hlth, Schwerzenbach, Switzerland;

    Ecole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, Lab Syst Biol & Genet, Lausanne, Switzerland;

    Ecole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, Lab Syst Biol & Genet, Lausanne, Switzerland;

    Ecole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, Lab Syst Biol & Genet, Lausanne, Switzerland;

    Eidgenoss Tech Hsch Zurich, Inst Food Nutr & Hlth, Schwerzenbach, Switzerland;

    Swiss Stem Cell Fdn, Gentilino, Switzerland;

    Eidgenoss Tech Hsch Zurich, Inst Food Nutr & Hlth, Schwerzenbach, Switzerland;

    Concept Clin, Geneva, Switzerland;

    Swiss Stem Cell Fdn, Gentilino, Switzerland;

    Eidgenoss Tech Hsch Zurich, Inst Food Nutr & Hlth, Schwerzenbach, Switzerland;

    Ecole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, Lab Syst Biol & Genet, Lausanne, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号