T cells from patients with Parkinson's disease recognize alpha-synuclein peptides

Sulzer David; Alcalay Roy N.; Garretti Francesca; Cote Lucien; Kanter Ellen; Agin-Liebes Julian; Liong Christopher; McMurtrey Curtis; Hildebrand William H.; Mao Xiaobo; Dawson Valina L.; Dawson Ted M.; Oseroff Carla; Pham John; Sidney John; Dillon Myles B.; Carpenter Chelsea; Weiskopf Daniela; Phillips Elizabeth; Mallal Simon; Peters Bjoern; Frazier April; Arlehamn Cecilia S. Lindestam; Sette Alessandro

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T cells from patients with Parkinson's disease recognize alpha-synuclein peptides

机译：帕金森氏病患者的T细胞可识别α-突触核蛋白肽

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Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex(1-3). Here we show that a defined set of peptides that are derived from a-synuclein, a protein aggregated in Parkinson's disease(4), act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

机译：遗传学研究表明帕金森氏病与主要组织相容性复合体的等位基因相关（1-3）。在这里，我们显示了一组衍生自a-突触核蛋白（一种在帕金森氏病中聚集的蛋白质）的确定的肽（4），充当这些等位基因显示的抗原表位，并在帕金森氏病患者中驱动辅助和细胞毒性T细胞反应。这些反应可以解释帕金森氏病与特定的主要组织相容性复杂等位基因的关联。

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《Nature》 |2017年第7660期|656-661|共6页
作者
Sulzer David; Alcalay Roy N.; Garretti Francesca; Cote Lucien; Kanter Ellen; Agin-Liebes Julian; Liong Christopher; McMurtrey Curtis; Hildebrand William H.; Mao Xiaobo; Dawson Valina L.; Dawson Ted M.; Oseroff Carla; Pham John; Sidney John; Dillon Myles B.; Carpenter Chelsea; Weiskopf Daniela; Phillips Elizabeth; Mallal Simon; Peters Bjoern; Frazier April; Arlehamn Cecilia S. Lindestam; Sette Alessandro;
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作者单位

Columbia Univ, Dept Psychiat, Div Molcular Therapeut, New York State Psychiat Inst, New York, NY 10032 USA|Columbia Univ, Dept Neurol, New York, NY 10032 USA|Columbia Univ, Dept Pharmacol, New York, NY 10032 USA;

Columbia Univ, Dept Neurol, New York, NY 10032 USA;

Columbia Univ, Dept Psychiat, Div Molcular Therapeut, New York State Psychiat Inst, New York, NY 10032 USA;

Columbia Univ, Dept Neurol, New York, NY 10032 USA;

Columbia Univ, Dept Psychiat, Div Molcular Therapeut, New York State Psychiat Inst, New York, NY 10032 USA;

Columbia Univ, Dept Psychiat, Div Molcular Therapeut, New York State Psychiat Inst, New York, NY 10032 USA;

Columbia Univ, Dept Neurol, New York, NY 10032 USA;

Univ Oklahoma, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA;

Univ Oklahoma, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA;

Johns Hopkins Univ, Sch Med, Neuroregenerat & Stem Cell Program, Inst Cell Engn, Baltimore, MD 21205 USA|Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA|Adrienne Helis Malvin Med Res Fdn, New Orleans, LA 70130 USA;

Johns Hopkins Univ, Sch Med, Neuroregenerat & Stem Cell Program, Inst Cell Engn, Baltimore, MD 21205 USA|Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA|Adrienne Helis Malvin Med Res Fdn, New Orleans, LA 70130 USA|Johns Hopkins Univ, Dept Physiol, Sch Med, Baltimore, MD 21205 USA|Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA;

Johns Hopkins Univ, Sch Med, Neuroregenerat & Stem Cell Program, Inst Cell Engn, Baltimore, MD 21205 USA|Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA|Adrienne Helis Malvin Med Res Fdn, New Orleans, LA 70130 USA|Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA|Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA;

La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA;

La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA;

La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA;

La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA;

La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA;

La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA;

Murdoch Univ, Inst Immunol & Infect Dis, Perth, WA 6150, Australia|Vanderbilt Univ, Sch Med, Nashville, TN 37235 USA;

Murdoch Univ, Inst Immunol & Infect Dis, Perth, WA 6150, Australia|Vanderbilt Univ, Sch Med, Nashville, TN 37235 USA;

La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA;

La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA;

La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA;

La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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专利

1. Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease [J] . Caggiu E., Paulus K., Galleri G., Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2017,第期

机译：同源HSV1和α-突触核蛋白肽刺激帕金森病中的T细胞反应
2. Clinical phenotype in patients with alpha-synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease. [J] . Papapetropoulos S, Paschalis C, Athanassiadou A, Journal of Neurology, Neurosurgery and Psychiatry . 2001,第5期

机译：与散发性帕金森病患者相比，居住在希腊的α-突触核蛋白帕金森病患者的临床表型。
3. Parkinson disease: Induced pluripotent stem cells-a new in vitro model to investigate alpha-synuclein dysfunction in Parkinson disease. [J] . Malpass K Nature reviews. Neurology . 2011,第10期

机译：帕金森氏病：诱导多能干细胞-一种新型的体外模型，用于研究帕金森氏病中的α-突触核蛋白功能障碍。
4. Gene Engineering of the Alpha-Synuclein Gene by CRISPR/Cas9 in Parkinson's Disease Patient-Derived Stem Cell Cultures [C] . Allen Kim, Birgitt Schuele International Molecular Medicine Tri-Conference. . 2015

机译：帕金森病患者衍生干细胞培养物中CRISPR / CAS9α-突触核蛋白基因的基因工程
5. Acrolein-mediated neuronal cell death and alpha-synuclein aggregation: Implication in Parkinson's Disease. [D] . Ambaw, Abeje S. 2012

机译：丙烯醛介导的神经元细胞死亡和α-突触核蛋白聚集：对帕金森氏病的影响。
6. T cells of Parkinson’s disease patients recognize α–synuclein peptides [O] . David Sulzer, Roy N. Alcalay, Francesca Garretti, -1

机译：帕金森氏病患者的T细胞识别α–突触核蛋白肽
7. T cells from patients with Parkinson’s disease recognize α-synuclein peptides [O] . David Sulzer, Roy N. Alcalay, Francesca Garretti, 2017

机译：来自帕金森病患者的T细胞识别α-突触核蛋白肽

T cells from patients with Parkinson's disease recognize alpha-synuclein peptides

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