• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
【24h】

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

机译：人类胎儿树突状细胞通过精氨酸酶2促进产前T细胞免疫抑制

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells(1,2), substances from ingested amniotic fluid(3,4), food antigens(5), and microbes(6). Yet the capacity of the fetal immune system, including antigen-presenting cells, to detect and respond to such stimuli remains unclear. In particular, dendritic cells, which are crucial for effective immunity and tolerance, remain poorly characterized in the developing fetus. Here we show that subsets of antigen-presenting cells can be identified in fetal tissues and are related to adult populations of antigen-presenting cells. Similar to adult dendritic cells, fetal dendritic cells migrate to lymph nodes and respond to toll-like receptor ligation; however, they differ markedly in their response to allogeneic antigens, strongly promoting regulatory T-cell induction and inhibiting T-cell tumour-necrosis factor-a production through arginase-2 activity. Our results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation.
机译：在妊娠期间，发育中的胎儿会暴露于多种潜在的免疫刺激分子中，包括来自母体细胞的半同种异体抗原（1,2），摄入的羊水中的物质（3,4），食物抗原（5）和微生物（6）。胎儿免疫系统，包括抗原呈递细胞，检测和响应这种刺激的能力仍不清楚。特别是，对于有效的免疫力和耐受性至关重要的树突状细胞，在发育中的胎儿中的特征仍然很差。在这里，我们显示抗原呈递细胞的子集可以在胎儿组织中鉴定出来，并与成年抗原呈递细胞群体有关。类似于成人树突状细胞，胎儿树突状细胞迁移至淋巴结并响应toll样受体结扎。但是，它们在对同种异体抗原的反应上有显着不同，它们通过精氨酸酶2的活性强烈促进调节性T细胞的诱导并抑制T细胞肿瘤坏死因子-a的产生。我们的研究结果揭示了发育中的胎儿中树突状细胞的先前未曾意识到的作用，并表明它们在妊娠过程中介导稳态免疫抑制反应。

著录项

  • 来源
    《Nature》 |2017年第7660期|662-666|共5页
  • 作者

    McGovern Naomi; Shin Amanda; Low Gillian; Low Donovan; Duan Kaibo; Yao Leong Jing; Msallam Rasha; Low Ivy; Shadan Nurhidaya Binte; Sumatoh Hermi R.; Soon Erin; Lum Josephine; Mok Esther; Hubert Sandra; See Peter; Kunxiang Edwin Huang; Lee Yie Hou; Janela Baptiste; Choolani Mahesh; Mattar Citra Nurfarah Zaini; Fan Yiping; Lim Tony Kiat Hon; Chan Dedrick Kok Hong; Tan Ker-Kan; Tam John Kit Chung; Schuster Christopher; Elbe-Buerger Adelheid; Wang Xiao-nong; Bigley Venetia; Collin Matthew; Haniffa Muzlifah; Schlitzer Andreas; Poidinger Michael; Albani Salvatore; Larbi Anis; Newell Evan W.; Chan Jerry Kok Yen; Ginhoux Florent;

  • 作者单位

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore|Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai 200025, Peoples R China;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    STIIC, 20 Coll Rd,Level 8 Discovery Tower, Singapore 169856, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    KK Womens & Childrens Hosp, Dept Reprod Med, Singapore 229899, Singapore;

    KK Womens & Childrens Hosp, KK Res Ctr, 100 Bukit Timah Rd, Singapore 229899, Singapore|Duke NUS Med Sch, OBGYN Acad Clin Program, Duke NUS, 8 Coll Rd, Singapore 169857, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore|Natl Univ Singapore, Yong Loo Lin Sch Med, Expt Fetal Med Grp, Singapore 119077, Singapore;

    Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore|Natl Univ Singapore, Yong Loo Lin Sch Med, Expt Fetal Med Grp, Singapore 119077, Singapore;

    KK Womens & Childrens Hosp, Dept Reprod Med, Singapore 229899, Singapore|Natl Univ Singapore, Yong Loo Lin Sch Med, Expt Fetal Med Grp, Singapore 119077, Singapore;

    Singapore Gen Hosp, Dept Pathol, 20 Coll Rd, Singapore 169856, Singapore;

    Natl Univ Hlth Syst, Univ Surg Cluster, Div Colorectal Surg, Singapore 119074, Singapore;

    Natl Univ Hlth Syst, Univ Surg Cluster, Div Colorectal Surg, Singapore 119074, Singapore|Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, 1E Kent Ridge Rd, Singapore 119228, Singapore;

    Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, 1E Kent Ridge Rd, Singapore 119228, Singapore;

    Med Univ Vienna, DIAID, Dept Dermatol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria;

    Med Univ Vienna, DIAID, Dept Dermatol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria;

    Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore|Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, 1E Kent Ridge Rd, Singapore 119228, Singapore|Univ Bonn, Myeloid Cell Biol Life & Med Sci Inst, D-53115 Bonn, Germany|German Ctr Neurodegenerat Dis, Single Cell Genom & Epigen Unit, D-53175 Bonn, Germany|Univ Bonn, D-53175 Bonn, Germany;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    STIIC, 20 Coll Rd,Level 8 Discovery Tower, Singapore 169856, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore|KK Womens & Childrens Hosp, Dept Reprod Med, Singapore 229899, Singapore|Natl Univ Singapore, Yong Loo Lin Sch Med, Expt Fetal Med Grp, Singapore 119077, Singapore|Duke NUS Grad Med Sch, Canc & Stem Cell Biol Program, Singapore 119077, Singapore;

    ASTAR, Singapore Immunol Network SIgN, 8A Biomed Grove,Immunos Bldg,Level 3 & 4, Singapore 138648, Singapore;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号