• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain
【24h】

Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain

机译：来自圆孔的证据表明祖先脊椎动物大脑的复杂区域化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The vertebrate brain is highly complex, but its evolutionary origin remains elusive. Because of the absence of certain developmental domains generally marked by the expression of regulatory genes, the embryonic brain of the lamprey, a jawless vertebrate, had been regarded as representing a less complex, ancestral state of the vertebrate brain. Specifically, the absence of a Hedgehog- and Nkx2.1-positive domain in the lamprey subpallium was thought to be similar to mouse mutants in which the suppression of Nkx2-1 leads to a loss of the medial ganglionic eminence1,2. Here we show that the brain of the inshore hagfish (Eptatretus burgeri), another cyclostome group, develops domains equivalent to the medial ganglionic eminence and rhombic lip, resembling the gnathostome brain. Moreover, further investigation of lamprey larvae revealed that these domains are also present, ruling out the possibility of convergent evolution between hagfish and gnathostomes. Thus, brain regionalization as seen in crown gnathostomes is not an evolutionary innovation of this group, but dates back to the latest vertebrate ancestor before the divergence of cyclostomes and gnathostomes more than 500 million years ago.
机译：脊椎动物的大脑非常复杂，但其进化起源仍然难以捉摸。由于缺少通常以调节基因的表达为特征的某些发育域，因此七rey鳗（一种无颚脊椎动物）的胚胎大脑被认为代表了脊椎动物大脑的一种较不复杂的祖先状态。具体而言，七lamp鳗亚皮层中不存在Hedgehog-和Nkx2.1阳性结构域类似于小鼠突变体，其中Nkx2-1的抑制导致内侧神经节突的丧失1,2。在这里，我们显示了另一个环栖动物群近海长尾鱼（Eptatretus burgeri）的大脑发育出相当于内侧神经节隆起和菱形唇的区域，类似于gnathostome大脑。此外，对七lamp鳗幼虫的进一步研究表明，这些域也存在，排除了ha鱼和钩虫之间趋同进化的可能性。因此，在冠状咬人动物中看到的脑区域化不是该群体的进化创新，而是可以追溯到5亿多年前圈回动物和咬人动物发散之前的最新脊椎动物祖先。

著录项

  • 来源
    《Nature》 |2016年第7592期|97-100|共4页
  • 作者

    Sugahara Fumiaki; Pascual-Anaya Juan; Oisi Yasuhiro; Kuraku Shigehiro; Aota Shin-ichi; Adachi Noritaka; Takagi Wataru; Hirai Tamami; Sato Noboru; Murakami Yasunori; Kuratani Shigeru;

  • 作者单位

    RIKEN, Evolutionary Morphol Lab, Kobe, Hyogo 6500047, Japan|Hyogo Coll Med, Div Biol, Nishinomiya, Hyogo 6638501, Japan;

    RIKEN, Evolutionary Morphol Lab, Kobe, Hyogo 6500047, Japan;

    Max Planck Florida Inst Neurosci, Dev & Funct Inhibitory Neural Circuits, Jupiter, FL 33458 USA;

    RIKEN, Ctr Life Sci Technol, Phyloinformat Unit, Kobe, Hyogo 6500047, Japan;

    RIKEN, Evolutionary Morphol Lab, Kobe, Hyogo 6500047, Japan;

    Univ Chicago, Dept Organismal Biol & Anat, 1025 E 57Th St, Chicago, IL 60637 USA;

    RIKEN, Evolutionary Morphol Lab, Kobe, Hyogo 6500047, Japan;

    RIKEN, Evolutionary Morphol Lab, Kobe, Hyogo 6500047, Japan;

    Niigata Univ, Grad Sch Med & Dent Sci, Div Gross Anat & Morphogenesis, Niigata 9508510, Japan;

    Ehime Univ, Grad Sch Sci & Engn, Matsuyama, Ehime 7908577, Japan;

    RIKEN, Evolutionary Morphol Lab, Kobe, Hyogo 6500047, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号