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Control of plant stem cell function by conserved interacting transcriptional regulators

机译：通过保守的相互作用转录调节子控制植物干细胞的功能

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摘要

Plant stem cells in the shoot apical meristem (SAM) and root apical meristem are necessary for postembryonic development of above-ground tissues and roots, respectively, while secondary vascular stem cells sustain vascular development. WUSCHEL (WUS), a homeo-domain transcription factor expressed in the rib meristem of the Arabidopsis SAM, is a key regulatory factor controlling SAM stem cell populations, and is thought to establish the shoot stem cell niche through a feedback circuit involving the CLAVATA3 (CLV3) peptide signalling pathway. WUSCHEL-RELATED HOMEOBOX 5 (WOX5), which is specifically expressed in the root quiescent centre, defines quiescent centre identity and functions interchangeably with WUS in the control of shoot and root stem cell niches. WOX4, expressed in Arabidopsis procambial cells, defines the vascular stem cell niche. WUS/WOX family proteins are evolutionarily and functionally conserved throughout the plant kingdom and emerge as key actors in the specification and maintenance of stem cells within all meristems. However, the nature of the genetic regime in stem cell niches that centre on WOX gene function has been elusive, and molecular links underlying conserved WUS/WOX function in stem cell niches remain unknown. Here we demonstrate that the Arabidopsis HAIRY MERISTEM (HAM) family of transcription regulators act as conserved interacting cofactors with WUS/WOX proteins. HAM and WUS share common targets in vivo and their physical interaction is important in driving downstream transcriptional programs and in promoting shoot stem cell proliferation. Differences in the overlapping expression patterns of WOX and HAM family members underlie the formation of diverse stem cell niche locations, and the HAM family is essential for all of these stem cell niches. These findings establish a new framework for the control of stem cell production during plant development.
机译：芽顶分生组织（SAM）和根顶端分生组织中的植物干细胞分别是地上组织和根的胚后发育所必需的，而次级血管干细胞则维持血管的发育。 WUSCHEL（WUS）是拟南芥SAM的分生组织中表达的一个同源域转录因子，是控制SAM干细胞种群的关键调节因子，被认为可以通过涉及CLAVATA3的反馈电路来建立芽干细胞的生态位。 CLV3）肽信号通路。与WUSCHEL相关的HOMEOBOX 5（WOX5），特别是在根部静止中心表达，定义了静止中心身份，并与WUS互换作用，可控制芽和根干细胞生态位。在拟南芥菌体细胞中表达的WOX4定义了血管干细胞的生态位。 WUS / WOX家族蛋白在整个植物界均在进化上和功能上均得到保守，并在所有分生组织中成为干细胞规范和维护中的关键角色。但是，以WOX基因功能为中心的干细胞生态位的遗传机制的性质难以捉摸，而干细胞生态位中保守的WUS / WOX功能的分子联系仍然未知。在这里，我们证明拟南芥的HAIRY MERISTEM（HAM）家族的转录调节因子充当与WUS / WOX蛋白质的保守相互作用辅因子。 HAM和WUS在体内具有共同的靶标，它们的物理相互作用对于驱动下游转录程序和促进茎干细胞增殖很重要。 WOX和HAM家族成员重叠表达模式的差异是形成不同干细胞生态位的基础，而HAM家族对于所有这些干细胞生态位至关重要。这些发现建立了在植物发育过程中控制干细胞生产的新框架。

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  • 来源
    《Nature》 |2015年第7534期|377-380|共4页
  • 作者

    Yun Zhou; Xing Liu; Eric M. Engstrom; Zachary L. Nimchuk; Jose L. Pruneda-Paz; Paul T. Tarr; An Yan; Steve A. Kay; Elliot M. Meyerowitz;

  • 作者单位

    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA;

    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA;

    Biology Department, College of William and Mary,Williamsburg, Virginia 23187-8795, USA,Department of Biology, Rollins College, Winter Park, Florida 32789, USA;

    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA,Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA,Department of Biological Sciences, Latham Hall RM 408, Virginia Tech, 220 Ag Quad Lane, Blacksburg, Virginia 24061, USA;

    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA;

    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA;

    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA;

    University of Southern California, Molecular and Computational Biology, Department of Biological Sciences, Dana and David Dornsife College of Letters, Arts and Sciences, Los Angeles, California 90089, USA;

    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA,Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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