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Global research priorities for infections that affect the nervous system

机译：影响神经系统感染的全球研究重点

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摘要

Infections that cause significant nervous system morbidity globally include viral (for example, HIV, rabies, Japanese encephalitis virus, herpes simplex virus, varicella zoster virus, cytomegalovirus, dengue virus and chikungunya virus), bacterial (for example, tuberculosis, syphilis, bacterial meningitis and sepsis), fungal (for example, cryptococcal meningitis) and parasitic (for example, malaria, neurocysticercosis, neuroschistosomiasis and soil-transmitted helminths) infections. The neurological, cognitive, behavioural or mental health problems caused by the infections probably affect millions of children and adults in low-and middle-income countries. However, precise estimates of morbidity are lacking for most infections, and there is limited information on the pathogenesis of nervous system injury in these infections. Key research priorities for infection-related nervous system morbidity include accurate estimates of disease burden; point-of-care assays for infection diagnosis; improved tools for the assessment of neurological, cognitive and mental health impairment; vaccines and other interventions for preventing infections; improved understanding of the pathogenesis of nervous system disease in these infections; more effective methods to treat and prevent nervous system sequelae; operations research to implement known effective interventions; and improved methods of rehabilitation. Research in these areas, accompanied by efforts to implement promising technologies and therapies, could substantially decrease the morbidity and mortality of infections affecting the nervous system in low-and middle-income countries.
机译：在全球范围内导致严重神经系统发病的感染包括病毒（例如，HIV，狂犬病，日本脑炎病毒，单纯疱疹病毒，水痘带状疱疹病毒，巨细胞病毒，登革热病毒和基孔肯雅病毒），细菌（例如，结核，梅毒，细菌性脑膜炎）和败血症），真菌（例如隐球菌性脑膜炎）和寄生虫（例如疟疾，神经囊虫病，神经血吸虫病和土壤传播的蠕虫）感染。由感染引起的神经，认知，行为或精神​​健康问题可能影响中低收入国家的数百万儿童和成人。但是，对于大多数感染，尚缺乏对发病率的精确估计，而且关于这些感染中神经系统损伤的发病机理的信息有限。与感染相关的神经系统发病率的关键研究重点包括准确估计疾病负担；用于感染诊断的即时检验；改进的评估神经，认知和心理健康损害的工具；预防感染的疫苗和其他干预措施；更好地了解这些感染中神经系统疾病的发病机制；更有效的方法来治疗和预防神经系统后遗症；进行研究以实施已知的有效干预措施；和改进的康复方法。在这些领域的研究，以及为实施有前途的技术和疗法而做出的努力，可能会大大降低影响中低收入国家神经系统的感染的发病率和死亡率。

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  • 来源
    《Nature》 |2015年第7578appa期|S178-S186|共9页
  • 作者

    John Chandy C.; Carabin Helene; Montano Silvia M.; Bangirana Paul; Zunt Joseph R.; Peterson Phillip K.;

  • 作者单位

    Indiana Univ Sch Med, Dept Pediat, Ryan White Ctr Pediat Infect Dis & Global Hlth, Indianapolis, IN 46202 USA;

    Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Biostat & Epidemiol, Oklahoma City, OK 73104 USA;

    US Naval Med Res, Dept Bacteriol, Unit 6, Lima, Peru;

    Makerere Univ, Dept Psychiat, Coll Hlth Sci, Kampala, Uganda;

    Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA;

    Univ Minnesota, Div Infect Dis & Int Med, Minneapolis, MN 55455 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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