Dopamine loss hurts diabetic eye

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Dopamine loss hurts diabetic eye

机译：多巴胺流失会伤害糖尿病眼

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A decrease in the amount of dopamine in the retina could explain why people with diabetes often have visual problems or even go blind. Reduced levels of this brain-signalling molecule have been seen in diabetes before, so Machelle Pardue at Emory University in Atlanta, Georgia, and her colleagues gave a dopamine precursor called L-DOPA to rat and mouse models of type 1 diabetes. They found that the molecule delayed the onset and slowed down the progression of early visual dysfunction, and improved the responses of the retinas light-sensing cells.

机译：视网膜中多巴胺含量的减少可以解释为什么糖尿病患者经常有视力障碍甚至失明。以前在糖尿病患者中发现这种大脑信号分子的含量降低，因此佐治亚州亚特兰大市埃默里大学的Machelle Pardue和她的同事们给1型糖尿病大鼠和小鼠模型提供了称为L-DOPA的多巴胺前体。他们发现该分子延迟了发作并减慢了早期视觉功能障碍的进程，并改善了视网膜感光细胞的反应。

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《Nature》 |2014年第7484期|456-456|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Oral protein kinase c beta inhibition using ruboxistaurin: efficacy, safety, and causes of vision loss among 813 patients (1,392 eyes) with diabetic retinopathy in the Protein Kinase C beta Inhibitor-Diabetic Retinopathy Study and the Protein Kinase C beta Inhibitor-Diabetic Retinopathy Study 2. [J] . Aiello LP, Vignati L, Sheetz MJ, Retina . 2011,第10期

机译：使用蛋白激酶Cβ抑制剂-糖尿病性视网膜病研究和蛋白激酶Cβ抑制剂-糖尿病性视网膜病研究中的使用Ruboxistaurin抑制口服蛋白激酶Cβ：有效性，安全性和813名糖尿病视网膜病患者（1,392眼）的视力丧失原因2。
2. Does delay in referral of proliferative diabetic retinopathy from the diabetic eye screening programme lead to visual loss? [J] . Negretti G. S., Amin R., Webster L., Eye . 2016,第6期

机译：糖尿病眼科筛查计划延迟转诊增生性糖尿病视网膜病变是否会导致视力下降？
3. Endothelial Cell Loss in Diabetic and Nondiabetic Eyes After Cataract Surgery [J] . He Xu, Diakonis Vasilios F., Alavi Yasamin, Cornea . 2017,第8期

机译：白内障手术后糖尿病和非糖尿病眼内皮细胞损失
4. Inhibitory Effects of Curcumin on Microvascular Dysfunction in Diabetic Rat Eyes: eye ointment versus oral administration [C] . Wongeakin N., Kasetsuwan N., Wirachwong P., Asian Congress for Microcirculation . 2011

机译：姜黄素对糖尿病大鼠眼微血管功能障碍的抑制作用：眼药膏与口服给药
5. Catalan that doesn't hurt the eyes: Linguistic display and linguistic regimentation in Barcelona. [D] . Frekko, Susan E. 2006

机译：不伤眼睛的加泰罗尼亚语：巴塞罗那的语言展示和语言划分。
6. Does delay in referral of proliferative diabetic retinopathy from the diabetic eye screening programme lead to visual loss? [O] . G S Negretti, R Amin, L Webster, 2016

机译：糖尿病眼科筛查计划延迟转诊增生性糖尿病视网膜病变是否会导致视力下降？
7. Does delay in referral of proliferative diabetic retinopathy from the diabetic eye screening programme lead to visual loss? [O] . G S Negretti, R Amin, L Webster, 2016

机译：从糖尿病眼部筛查程序中延迟增殖性糖尿病视网膜病变会导致视力丧失吗？

Dopamine loss hurts diabetic eye

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