Short RNAs and shortness of breath

IRMA SANCHEZ; BRIAN D. DYNLACHT

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Short RNAs and shortness of breath

机译：短RNA和呼吸急促

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Defects in the assembly of cilia - fine projections of the cell surface - are the cause of a plethora of human diseases. One such disease is primary ciliary dyskinesia, a syndrome that severely compromises the function of the respiratory tract and reproductive system, resulting in airway infections and infertility. Identification of factors that control the assembly of cilia would constitute a major scientific advance. In this issue, Song et al. (page 115) implicate clusters of non-protein-coding RNA molecules in the regulation of cilium assembly, and show that deletion of these regulators in mice leads to a syndrome reminiscent of primary ciliary dyskinesia.

机译：纤毛的组装缺陷-细胞表面的细微突起-是导致大量人类疾病的原因。一种这样的疾病是原发性睫状运动障碍，该综合征严重损害呼吸道和生殖系统的功能，导致气道感染和不育。确定控制纤毛组装的因素将构成重大的科学进展。在本期中，Song等。（第115页）将非蛋白质编码RNA分子簇包含在纤毛组装的调节中，并显示小鼠中这些调节子的缺失会导致综合征，使人联想到原发性睫状运动障碍。

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来源
《Nature》 |2014年第7503期|40-42|共3页
作者
IRMA SANCHEZ; BRIAN D. DYNLACHT;
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作者单位

New York University School of Medicine,New York, New York 10016, USA;

New York University School of Medicine,New York, New York 10016, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. A differential comes up short in a patient with shortness of breath [J] . Duy Ha, Steven McKee Respiratory Medicine Case Reports . 2020,第3期

机译：患有呼吸急促的患者中差异出现
2. Short of breath, short of benefit: important considerations for the rehabilitation of IPF patients. [J] . Eves ND, Koelwyn GJ Respirology : . 2011,第8期

机译：呼吸急促，利益不足：IPF患者康复的重要考虑因素。
3. Short of breath, not short of diagnoses. [J] . Di Francesco L, Mora L, Leeper K Journal of Hospital Medicine . 2009,第1期

机译：呼吸急促，并非缺乏诊断。
4. CONSTRUCTION OF MOLECULAR CATCHERS FOR SHORT NON-CODING RNA (SHORT NCRNA) USING MUTANT RIBONUCLEASE 1-AND PAZ DOMAIN-DISPLAYING YEASTS [C] . Natsuko Miura, Eri Hayashi, Hironobu Morisaka, The 6'th International Forum on Post-genome Technologies(6'IFPT)（第六届国际后基因组生命科学技术学术论坛） . 2009

机译：用突变核糖核酸酶1-和PAZ域显示酶构建短链非编码RNA分子分子
5. Short of breath: A social and intellectual history of asthma in the United States [D] . Keirns, Carla Christine 2004

机译：呼吸急促：美国有哮喘的社交和知识史
6. Short RNAs and shortness of breath [O] . IRMA SÁNCHEZ, BRIAN D. DYNLACHT -1

机译：短RNA和呼吸急促
7. 160 Study of shortness of breath (SOB) point-of-care biomarker panel in patients presenting with shortness of breath in emergency department [O] . Tanmay Kumar Jha 2020

机译：160呼吸短促呼吸短促（SOB）患者患者患者急诊急促呼吸急促的研究

Short RNAs and shortness of breath

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