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Nature insight

机译:自然洞察力

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摘要

Lipids are small hydrophobic molecules that carry out a multitude of crucial roles. For example, they act as structural elements in biological membranes, they store energy and they function as signalling molecules in cellular response pathways. Disruption to their levels of expression - as occurs in obesity, diabetes, autoimmunity or inborn errors of lipid metabolism - leads to dysfunction and disease in many organs. In this Insight, Joost Holthuis and Anant Menon begin by discussing the cellular pathways by which eukaryotic cells maintain a variety of lipid compositions in different organelles so that they can carry out their specialized tasks.
机译:脂质是小的疏水分子,可发挥多种关键作用。例如,它们在生物膜中充当结构元件,它们存储能量,并在细胞反应途径中充当信号分子。它们的表达水平受到破坏(例如在肥胖症,糖尿病,自身免疫或脂质代谢的先天性错误中发生),导致许多器官功能障碍和疾病。在此见解中,Joost Holthuis和Anant Menon首先讨论了真核细胞在不同细胞器中维持多种脂质组成的细胞途径,以便他们可以执行其专门任务。

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