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Receptor binding by H10 influenza viruses

机译：H10流感病毒与受体的结合

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流感病毒H10N8是感染人类、并致人死亡的一种禽流感病毒的最新例证。Steven Gamblin及同事研究了一种禽流感病毒H10(它与人类分离毒株密切相关)的血凝素的结构和受体结合特点。他们发现,H10病毒已经能够与人类受体相结合,尽管它明显喜好禽类受体。结合到其人类受体上的H10血凝素的结构,还显示了与来自流行性H1N1病毒和H7N9病毒的血凝素特点的相似性。作者提出,H10血凝素的受体结合点的突变(这种突变会降低其对禽类受体的亲和力)也许使其能够更容易地在人类之间进行传播,所以应当是监测工作的重点。%H10N8 follows H7N9 and H5N1 as the latest in aline of avian influenza viruses that cause serious disease in humans and have become a threat to public health. Since December 2013, three human cases of H10N8 infection have been reported, two of whom are known to have died. To gather evidence relating to the epidemic potential of H10 we have determined the structure of the haemagglutinin of a previously isolated avian H10 virus and we present here results relating especially to its receptor-binding properties, as these are likely to be major determinants of virus transmissibility. Our results show, first, that the H10 virus possesses high avidity for human receptors and second, from the crystal structure of the complex formed by avian H10 haemagglutinin with human receptor, it is clear that the conformation of the bound receptor has characteristics of both the 1918 H1N1 pandemic virus and the human H7 viruses isolated from patients in 2013 (ref. 3). We conclude that avian H10N8 virus has sufficient avidity for human receptors to account for its infection of humans but that its preference for avian receptors should make avian-receptor-rich human airway mucins an effective block to widespread infection. In terms of surveillance, particular attention will be paid to the detection of mutations in the receptor-binding site of the H10 haemagglutinin that decrease its avidity for avian receptor, and could enable it to be more readily transmitted between humans.
机译：流感病毒H10N8是感染人类、并致人死亡的一种禽流感病毒的最新例证。Steven Gamblin及同事研究了一种禽流感病毒H10(它与人类分离毒株密切相关)的血凝素的结构和受体结合特点。他们发现,H10病毒已经能够与人类受体相结合,尽管它明显喜好禽类受体。结合到其人类受体上的H10血凝素的结构,还显示了与来自流行性H1N1病毒和H7N9病毒的血凝素特点的相似性。作者提出,H10血凝素的受体结合点的突变(这种突变会降低其对禽类受体的亲和力)也许使其能够更容易地在人类之间进行传播,所以应当是监测工作的重点。%H10N8 follows H7N9 and H5N1 as the latest in aline of avian influenza viruses that cause serious disease in humans and have become a threat to public health. Since December 2013, three human cases of H10N8 infection have been reported, two of whom are known to have died. To gather evidence relating to the epidemic potential of H10 we have determined the structure of the haemagglutinin of a previously isolated avian H10 virus and we present here results relating especially to its receptor-binding properties, as these are likely to be major determinants of virus transmissibility. Our results show, first, that the H10 virus possesses high avidity for human receptors and second, from the crystal structure of the complex formed by avian H10 haemagglutinin with human receptor, it is clear that the conformation of the bound receptor has characteristics of both the 1918 H1N1 pandemic virus and the human H7 viruses isolated from patients in 2013 (ref. 3). We conclude that avian H10N8 virus has sufficient avidity for human receptors to account for its infection of humans but that its preference for avian receptors should make avian-receptor-rich human airway mucins an effective block to widespread infection. In terms of surveillance, particular attention will be paid to the detection of mutations in the receptor-binding site of the H10 haemagglutinin that decrease its avidity for avian receptor, and could enable it to be more readily transmitted between humans.

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  • 来源
    《Nature》 |2014年第7510期|475-477b1|共4页
  • 作者

    Sebastien G. Vachieri; Xiaoli Xiong; Patrick J. Collins; Philip A. Walker; Stephen R. Martin; Lesley F. Haire; Ying Zhang; John W. McCauley; Steven J. Gamblin; John J. Skehel;

  • 作者单位

    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;

    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;

    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;

    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;

    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;

    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;

    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;

    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;

    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;

    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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