Microbiome science needs a healthy dose of scepticism

William P. Hanage

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Microbiome science needs a healthy dose of scepticism

机译：微生物组科学需要健康的怀疑态度

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Explorations of how the microscopic communities that inhabit the human body might contribute to health or disease have moved from obscure to ubiquitous. Over the past five years, studies have linked our microbial settlers to conditions as diverse as autism, cancer and diabetes. This excitement has infected the public imagination. 'We Are Our Bacteria', proclaimed one headline in The New York Times. Some scientists have asserted that antibiotics are causing a great extinction of the microbiome, with dire consequences for human health. Companies offer personalized analysis of the microbial content of faecal samples, promising consumers enlightening information. Separate analyses from the same person can, however, vary considerably, even from the same stool sample. Faecal transplants have been proposed - some more sensible than others - for conditions ranging from diabetes to Alzheimer's disease. With how-to instructions proliferating online, desperate patients must be warned not to attempt these risky procedures on themselves.

机译：关于居住在人体上的微观群落如何促进健康或疾病的探索已从晦涩难懂变为无处不在。在过去的五年中，研究已将我们的微生物定居者与自闭症，癌症和糖尿病等多种疾病联系起来。这种激动感染了公众的想象力。《纽约时报》宣称“我们是细菌”。一些科学家断言，抗生素正在使微生物组大量灭绝，给人类健康带来可怕的后果。公司提供粪便样品微生物含量的个性化分析，为消费者提供启发性信息。但是，即使是同一粪便样品，同一个人的单独分析也可能有很大差异。已经提出了从糖尿病到阿尔茨海默氏病的范围的粪便移植物，其中一些比其他的更为明智。随着在线使用说明的泛滥，必须警告绝望的患者不要对自己进行这些危险的操作。

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《Nature》 |2014年第7514期|247-248|共2页
作者
William P. Hanage;
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作者单位

Harvard School of Public Health in Boston, Massachusetts, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. All You Need is Love (Plus a Good Evidence Base, a Healthy Dose of Scepticism, and Patience and Perseverance in Working with Families!) [J] . Sidebotham Peter Child abuse review ejournal of the British Association for the Study and Prevention of Child Abuse and Neglect . 2017,第5期

机译：你所需要的只是爱（加上一个好的证据基础，健康剂量的怀疑，以及与家庭合作的耐心和坚持不懈！）
2. A healthy dose of scepticism: four good reasons to think again about protective effects of alcohol on coronary heart disease. [J] . Chikritzhs T, Fillmore K, Stockwell T Drug and alcohol review . 2009,第4期

机译：健康的怀疑态度：再次考虑酒精对冠心病的保护作用的四个充分理由。
3. Host: Microbiome co-metabolic processing of dietary polyphenols - An acute, single blinded, cross-over study with different doses of apple polyphenols in healthy subjects [J] . Trost Kajetan, Ulaszewska Maria M., Stanstrup Jan, Food research international . 2018,第OCTa期

机译：主持人：饮食中多酚的微生物组协同代谢加工-健康受试者中不同剂量苹果多酚的急性，单盲，交叉研究
4. Graph-based Analysis of Genetic Features Associated with Mobile Elements in Crohn's Disease and Healthy Gut Microbiomes [C] . Julia Warnke-Sommer, Hesham Ali International Conference on Bioinformatics Models, Methods and Algorithms . 2017

机译：基于图谱的遗传特征分析与Crohn病和健康肠道微生物中的移动元件相关
5. Influence of Four Differently Processed Diets on Plasma Levels of Advanced Glycation End Products (Ages), Serum Levels of Receptor for Advanced Glycation End Products (Rage), Serum and Urine Metabolome, and Fecal Microbiome in Healthy Dogs [D] . ?Bridglalsingh, Siobhan 2020

机译：四种不同加工饮食对晚期糖糖末端产物（年龄），晚期糖糖末端产物（RAGE），血清和尿液代谢的血清受体水平的影响，以及健康犬的粪便微生物组
6. Species-level bacterial community profiling of the healthy sinonasal microbiome using Pacific Biosciences sequencing of full-length 16S rRNA genes [O] . Joshua P. Earl, Nithin D. Adappa, Jaroslaw Krol, 2018

机译：使用Pacific Biosciences全长16S rRNA基因测序对健康鼻窦微生物组进行物种级细菌群落分析
7. All You Need is Love (Plus a Good Evidence Base, a Healthy Dose of Scepticism, and Patience and Perseverance in Working with Families!) [O] . Peter Sidebotham 2017

机译：你所需要的只是爱（加上一个好的证据基础，健康剂量的怀疑，以及与家庭合作的耐心和坚持不懈！）

Microbiome science needs a healthy dose of scepticism

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